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. 2014 Sep 30;9(9):e109030. doi: 10.1371/journal.pone.0109030

Figure 4. Effect of anti-emetic medication on body weight and mean food intake.

Figure 4

Mice were treated with 4 mg/kg cisplatin (CIS) or saline (Control) once weekly for 6 weeks and received concomitant ondansetron (Zofran) or dexamethasone (DEXA) for 3 consecutive days after each cisplatin treatment. A) Mean food intake, and B) change in body weight. Statistical analysis was performed by oneway ANOVA with Bonferroni's post hoc test (Mean ± SEM, N = 10). *P<0.05, ***P<0.001 compared with Control mice. Linear regression analyses between mean food intake (calculated from 3–5 cages per group) and change in body weight (C+D) (mean of mice in each cage), or change in lean body mass (E+F) (mean of mice in each cage) in non-exercising cisplatin-treated groups (CIS, CIS+Zofran and CIS+DEXA) and exercising cisplatin-treated groups (CIS+DEXA+EX and CIS+EX) were performed.