Table 1. Treatment completion rates.
Group | Treatment | Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 |
Study 1 | |||||||
1 | CON | 100% (16/16) | 100% (16/16) | 100% (16/16) | 100% (16/16) | 100% (16/16) | 100% (16/16) |
2 | CIS | 100% (16/16) | 100% (16/16) | 100% (16/16) | 100% (16/16) | 87% (14/16) | 87% (14/16) |
3 | CON + EX | 100% (18/18) | 100% (18/18) | 100% (18/18) | 100% (18/18) | 100% (18/18) | 100% (18/18) |
4 | CIS + EX | 100% (18/18) | 100% (18/18) | 100% (18/18) | 100% (18/18) | 100% (18/18) | 100% (18/18) |
Study 2 | |||||||
1 | CON | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) |
2 | CIS | 100% (10/10) | 100% (10/10) | 100% (10/10) | 90% (9/10) | 80% (8/10) | 80% (8/10) |
3 | CIS + ONS | 100% (10/10) | 100% (10/10) | 100% (10/10) | 90% (9/10) | 90% (9/10) | 80% (9/10) |
4 | CIS + STER | 100% (9/9) | 100% (9/9) | 100% (9/9) | 88% (8/9) | 88% (8/9) | 78% (7/9) |
5 | CIS + STER + EX | 100% (10/10) | 100% (10/10) | 100% (10/10) | 100% (10/10) | 100% (10/10) | 90% (9/10) |
6 | CIS + EX | 100% (10/10) | 100% (10/10) | 100% (10/10) | 100% (10/10) | 100% (10/10) | 100% (10/10) |
Study 3 | |||||||
1 | CON | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) |
2 | CIS | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) |
3 | CIS + EX in recovery | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) | 100% (9/9) |
Percentage and number of mice completing cisplatin treatment. CON: Saline treated mice, CIS: cisplatin treated mice, ONS: Onsedansetron, STER: steroids, dexamethasone, EX: access to running wheels, and CIS + EX in recovery: access to running wheels in the 6 weeks recovery phase.
In study 1 in each group, the mice were divided between termination at rest or after 1 hour of acute exercise (swimming). Both groups had the following measurements made: body weight, food intake, weight of organs at termination and blood sampling at termination. In addition, the rest group were DXA scanned, performed the hang tests and had a glucose tolerance test made.