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. 2014 Sep 30;9(9):e109030. doi: 10.1371/journal.pone.0109030

Table 1. Treatment completion rates.

Group Treatment Week 1 Week 2 Week 3 Week 4 Week 5 Week 6
Study 1
1 CON 100% (16/16) 100% (16/16) 100% (16/16) 100% (16/16) 100% (16/16) 100% (16/16)
2 CIS 100% (16/16) 100% (16/16) 100% (16/16) 100% (16/16) 87% (14/16) 87% (14/16)
3 CON + EX 100% (18/18) 100% (18/18) 100% (18/18) 100% (18/18) 100% (18/18) 100% (18/18)
4 CIS + EX 100% (18/18) 100% (18/18) 100% (18/18) 100% (18/18) 100% (18/18) 100% (18/18)
Study 2
1 CON 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9)
2 CIS 100% (10/10) 100% (10/10) 100% (10/10) 90% (9/10) 80% (8/10) 80% (8/10)
3 CIS + ONS 100% (10/10) 100% (10/10) 100% (10/10) 90% (9/10) 90% (9/10) 80% (9/10)
4 CIS + STER 100% (9/9) 100% (9/9) 100% (9/9) 88% (8/9) 88% (8/9) 78% (7/9)
5 CIS + STER + EX 100% (10/10) 100% (10/10) 100% (10/10) 100% (10/10) 100% (10/10) 90% (9/10)
6 CIS + EX 100% (10/10) 100% (10/10) 100% (10/10) 100% (10/10) 100% (10/10) 100% (10/10)
Study 3
1 CON 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9)
2 CIS 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9)
3 CIS + EX in recovery 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9) 100% (9/9)

Percentage and number of mice completing cisplatin treatment. CON: Saline treated mice, CIS: cisplatin treated mice, ONS: Onsedansetron, STER: steroids, dexamethasone, EX: access to running wheels, and CIS + EX in recovery: access to running wheels in the 6 weeks recovery phase.

In study 1 in each group, the mice were divided between termination at rest or after 1 hour of acute exercise (swimming). Both groups had the following measurements made: body weight, food intake, weight of organs at termination and blood sampling at termination. In addition, the rest group were DXA scanned, performed the hang tests and had a glucose tolerance test made.