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. 2014 Oct 1;9(10):e106455. doi: 10.1371/journal.pone.0106455

Table 4. Differences in individual risk predictions between risk scores and risks estimated using competing risk regression stratified by risk factors (selected results for larger differences).

Framingham risk score ASSIGN risk score QRISK2 risk score
Risk factor Mean difference with risks estimated using competing risk regression Percentage of persons with difference between −2 and +2% Mean difference with risks estimated using competing risk regression Percentage of persons with difference between −2 and +2% Mean difference with risks estimated using competing risk regression Percentage of persons with difference between −2 and +2%
Gender Men 3.7 24.0 1.7 24.8 0.4 47.5
Women 0.8 54.2 1.0 58.5 0.4 63.6
Age at index 35–44 2.0 58.9 1.5 59.9 0 84.4
45–54 3.2 31.8 1.2 39.6 0 53.3
55–64 2.8 22.2 0.5 24.1 0.3 26.5
65–74 0.7 19.6 2.4 18.2 2.2 18.5
Calendar year index 1998–2000 −0.7 32.0 −1.7 34.6 −3.2 42.3
2001–2003 1.6 38.0 0.6 39.8 −0.5 49.8
2004–2006 2.8 41.2 1.9 44.3 1.0 57.5
2007–2009 3.6 41.6 2.8 44.7 2.1 62.4
2010–2011 3.8 42.3 3.1 44.0 2.2 66.1
Ethnicity White 0 46.9 −0.7 51.1 −1.5 53.3
Black 2.6 52.0 2.0 56.1 0 77.6
Indian 2.5 46.2 −0.7 62.7 −0.2 64.7
Unknown 5.1 27.9 4.1 27.9 2.8 56.8
Diabetes mellitus no 2.2 39.6 1.2 42.2 0.3 56.3
yes 3.3 17.6 7.7 13.3 3.6 18.7
Left ventricular hypertrophy no 2.3 39.2 1.4 41.7 0.4 55.7
yes 1.1 12.1 −15.2 11.4 −11.9 13.3
Number of records for medical events in the electronic health records in the year before 0 4.9 26.7 3.4 26.3 1.6 58.0
1–3 3.9 34.8 2.7 36.3 1.1 60.2
4–8 2.8 42.3 1.8 45.6 0.5 60.8
9–18 1.7 43.6 0.9 47.4 0.1 55.3
19–4 0.1 43.5 −0.3 46.9 −0.5 48.7
50+ −2.6 37.3 −2.7 38.7 −1.9 37.6