Table 4. Differences in individual risk predictions between risk scores and risks estimated using competing risk regression stratified by risk factors (selected results for larger differences).
Framingham risk score | ASSIGN risk score | QRISK2 risk score | |||||
Risk factor | Mean difference with risks estimated using competing risk regression | Percentage of persons with difference between −2 and +2% | Mean difference with risks estimated using competing risk regression | Percentage of persons with difference between −2 and +2% | Mean difference with risks estimated using competing risk regression | Percentage of persons with difference between −2 and +2% | |
Gender | Men | 3.7 | 24.0 | 1.7 | 24.8 | 0.4 | 47.5 |
Women | 0.8 | 54.2 | 1.0 | 58.5 | 0.4 | 63.6 | |
Age at index | 35–44 | 2.0 | 58.9 | 1.5 | 59.9 | 0 | 84.4 |
45–54 | 3.2 | 31.8 | 1.2 | 39.6 | 0 | 53.3 | |
55–64 | 2.8 | 22.2 | 0.5 | 24.1 | 0.3 | 26.5 | |
65–74 | 0.7 | 19.6 | 2.4 | 18.2 | 2.2 | 18.5 | |
Calendar year index | 1998–2000 | −0.7 | 32.0 | −1.7 | 34.6 | −3.2 | 42.3 |
2001–2003 | 1.6 | 38.0 | 0.6 | 39.8 | −0.5 | 49.8 | |
2004–2006 | 2.8 | 41.2 | 1.9 | 44.3 | 1.0 | 57.5 | |
2007–2009 | 3.6 | 41.6 | 2.8 | 44.7 | 2.1 | 62.4 | |
2010–2011 | 3.8 | 42.3 | 3.1 | 44.0 | 2.2 | 66.1 | |
Ethnicity | White | 0 | 46.9 | −0.7 | 51.1 | −1.5 | 53.3 |
Black | 2.6 | 52.0 | 2.0 | 56.1 | 0 | 77.6 | |
Indian | 2.5 | 46.2 | −0.7 | 62.7 | −0.2 | 64.7 | |
Unknown | 5.1 | 27.9 | 4.1 | 27.9 | 2.8 | 56.8 | |
Diabetes mellitus | no | 2.2 | 39.6 | 1.2 | 42.2 | 0.3 | 56.3 |
yes | 3.3 | 17.6 | 7.7 | 13.3 | 3.6 | 18.7 | |
Left ventricular hypertrophy | no | 2.3 | 39.2 | 1.4 | 41.7 | 0.4 | 55.7 |
yes | 1.1 | 12.1 | −15.2 | 11.4 | −11.9 | 13.3 | |
Number of records for medical events in the electronic health records in the year before | 0 | 4.9 | 26.7 | 3.4 | 26.3 | 1.6 | 58.0 |
1–3 | 3.9 | 34.8 | 2.7 | 36.3 | 1.1 | 60.2 | |
4–8 | 2.8 | 42.3 | 1.8 | 45.6 | 0.5 | 60.8 | |
9–18 | 1.7 | 43.6 | 0.9 | 47.4 | 0.1 | 55.3 | |
19–4 | 0.1 | 43.5 | −0.3 | 46.9 | −0.5 | 48.7 | |
50+ | −2.6 | 37.3 | −2.7 | 38.7 | −1.9 | 37.6 |