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. 2014 Sep 17;2014:568693. doi: 10.1155/2014/568693

Figure 2.

Figure 2

SMI-dependent death of HROC24 cells. HROC24 cells growing in 12-well plates were treated with SMI and combinations thereof for 48 h as indicated. Afterwards, they were subjected to (a) cytofluorometric quantification of dead (PI-positive) cells, (b) determination of cell death by trypan blue staining, and (c) detection of apoptotic (Sub-G1 peak) cells. The portion of dead/apoptotic cells is expressed as percent of the total cell count. Data from n ≥ 6 separate cultures were used to calculate mean values ± SEM. (a): *P < 0.001 versus control cells cultured without SMI and # P < 0.002 versus cells cultured with single SMI with Bonferroni-adjusted α = 0.00294; (b): *P < 0.008 versus control cultures with Bonferroni-adjusted α = 0.0125; (c): *P < 0.001 versus control cultures with Bonferroni-adjusted α = 0.00625.