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. 2014 Oct 1;9(10):e108790. doi: 10.1371/journal.pone.0108790

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© 2014 Roldán Urgoiti et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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HPV 16 negative (top panels) and an HPV 16 positive (bottom panels) cases by subtyping, using HPV CISH (left panels), p16 IHC (middle panels), and p16 AQUA (right panels). P16 AQUA images are pseudo-colored red for p16, green for pan-cytokeratin (epithelial cell/tumor marker), and blue for DAPI (nuclear stain).