Table 3. Univariate analysis: 5-year overall survival (OS).

VARIABLE	5-year OS HR (95% CI)	P value
Gender (female vs male)	0.58 (0.32–1.04)	0.075
Age	1.01 (0.99–1.04)	0.26
ECOG PS	3.2 (2.2–4.6)	<0.0001
Tumor size ≥4 cm	2.8 (1.3–5.9	0.008
Nodal status (positive vs negative)	2.43 (1.09–5.42)	0.029
Pre-treatment Hb<120 g/L	4.5 (2.3–9.1)	<0.0001
RT vs CRT	3.86 (2.03–7.35)	<0.0001
Response at three months	0.35 (0.23–0.53)	<0.0001
P16 DAB score	0.90 (9.49–1.65)	0.75
P16 DAB score 3	0.38 (0.12–1.22)	0.09
HPV16 CISH	1.23 (0.64–2.38)	0.52
P16 AQUA tumor score, quartiles	1st – 0.61 (0.18–2.08)	0.43
	2nd – 1.55 (0.49–4.86)	0.45
	3rd – 0.61 (0.17–2.18)	0.45
	4th – 1.0
P16 AQUA tumor score>244	2.34 (0.84–6.54)	0.09
P16 AQUA tumor score>244 and higher pretreatment Hb (≥120 g/L)	4.5 (1.4–15)	0.01

ECOG PS: Eastern Cooperative Oncology Group Performance Status; RT: radiotherapy; CRT: chemoradiotherapy; Hb: hemoglobin; DAB: diaminobenzydene; CISH: chromogenic in situ hybridization.