Table 6.

Effect of methanolic extract of C. nurvala leaf on Involvement of ATP-sensitive K ⁺ channel pathway

Treatment	Dose (mg/kg)	Responses
		Number of writhing (Mean ± SEM)	% Inhibition
Control	0.1 ml/mouse	73.90 ± 1.61	-
Diclofenac sodium	10	19.90 ± 0.53*	73.07
MECN	50	54.70 ± 1.83*	25.98
MECN	100	29.90 ± 0.66*	59.54
MECN	200	18.30 ± 1.25*	75.24
Glib	10	75.1 ± 2.01	−1.62
Glib + Diclofenac-sodium	10 + 10	36.20 ± 1.77a	51.05
Glib + MECN	10 + 50	50.00 ± 1.53	32.34
Glib + MECN	10 + 100	28.00 ± 2.13	62.11
Glib + MECN	10 + 200	20.00 ± 1.34	72.94

Each value is presented as the Mean ± SEM (n = 5). MECN = Methanolic extract of. Crataeva nurvala leaves; Glib = Glibenclemide.

*p < 0.001 compared with the control group (Dunnett’s test).

^a p < 0.001 compared with the Diclofenac sodium treated group (Bonferroni’s test).