Table 1.
Activation index (%) by region of interest (ROI) analysis in different conditions of SNI and sham groups
| ROIs | SNI group (n = 12) | Sham group (n = 10) | ||||
|---|---|---|---|---|---|---|
| Naïve | SNI | GBP | Naïve | Sham | GBP | |
| mPFC i | 36.5 ± 2.1 | 35.2 ± 2.0 | * 29.6 ± 1.1 | 34.6 ± 2.2 | 35.9 ± 1.3 | 31.5 ± 1.6 |
| mPFC c | 37.9 ± 1.8 | 35.0 ± 2.0 | * 29.7 ± 1.2 | 33.1 ± 2.2 | 33.5 ± 1.5 | 28.6 ± 2.0 |
| ACC i | 36.9 ± 1.7 | 37.4 ± 2.6 | * 31.4 ± 1.3 | 37.3 ± 1.8 | 37.9 ± 1.5 | 34.1 ± 2.8 |
| ACC c | 34.7 ± 1.4 | 35.6 ± 2.6 | 32.3 ± 1.4 | 34.5 ± 1.8 | 35.8 ± 1.9 | 32.2 ± 2.8 |
| RSC i | 20.0 ± 1.7 | # 14.8 ± 2.4 | 14.5 ± 2.1 | 18.9 ± 1.7 | 15.1 ± 2.3 | 15.4 ± 2.4 |
| RSC c | 20.2 ± 1.6 | # 14.8 ± 2.3 | 13.7 ± 2.2 | 18.8 ± 1.9 | 15.0 ± 2.8 | 15.0 ± 2.8 |
| IC i | 1.4 ± 1.5 | # 4.8 ± 1.4 | 3.6 ± 1.8 | 1.3 ± 2.1 | 0.3 ± 2.1 | 1.6 ± 3.1 |
| IC c | 1.3 ± 1.4 | # 5.1 ± 1.5 | 3.6 ± 1.6 | 1.4 ± 2.0 | 0.5 ± 2.1 | 1.5 ± 3.0 |
| S1HL i | 14.7 ± 1.3 | 15.7 ± 1.3 | 15.1 ± 2.0 | 15.3 ± 1.6 | 12.3 ± 1.5 | 13.0 ± 3.1 |
| S1HL c | 15.3 ± 1.6 | 15.7 ± 1.6 | 15.2 ± 1.1 | 13.5 ± 2.3 | 12.5 ± 1.6 | 13.0 ± 3.0 |
| S1BF i | 18.7 ± 0.9 | 18.0 ± 1.6 | ** 25.0 ± 1.0 | 18.5 ± 1.3 | 18.5 ± 1.1 | 21.5 ± 2.4 |
| S1BF c | 18.6 ± 1.0 | 18.7 ± 1.5 | ** 25.7 ± 1.0 | 18.5 ± 1.3 | 17.6 ± 0.8 | 22.6 ± 2.4 |
| S1ULp i | 19.4 ± 1.6 | 19.7 ± 1.5 | *** 27.2 ± 1.2 | 21.8 ± 1.3 | 22.6 ± 1.8 | 25.9 ± 2.0 |
| S1ULp c | 17.9 ± 1.5 | 19.3 ± 1.6 | ** 27.1 ± 1.4 | 22.3 ± 2.0 | 21.1 ± 0.9 | 24.0 ± 2.2 |
| S2 | 9.8 ± 1.9 | 10.4 ± 1.7 | * 16.4 ± 1.9 | 11.9 ± 1.4 | 10.4 ± 1.8 | 15.2 ± 2.0 |
| S2 | 10.4 ± 2.2 | 10.8 ± 1.8 | ** 20.1 ± 1.4 | 14.3 ± 1.7 | 10.8 ± 1.3 | 13.6 ± 2.1 |
| M1 i | 14.1 ± 2.3 | 15.2 ± 1.5 | 15.5 ± 0.8 | 16.2 ± 1.8 | 15.3 ± 2.0 | 16.7 ± 3.1 |
| M1 c | 13.9 ± 2.9 | 13.3 ± 1.8 | 16.1 ± 1.1 | 14.6 ± 1.7 | 15.3 ± 2.1 | 15.2 ± 2.8 |
| CPu i | 31.8 ± 1.6 | 28.6 ± 1.9 | 28.6 ± 1.3 | 28.6 ± 1.5 | 28.9 ± 1.4 | 28.7 ± 2.2 |
| CPu c | 33.7 ± 1.2 | 28.8 ± 1.9 | 29.7 ± 1.4 | 30.4 ± 1.4 | 28.9 ± 1.5 | 29.5 ± 2.2 |
| Po i | 21.4 ± 1.1 | # 26.2 ± 1.6 | ** 21.0 ± 1.3 | 22.2 ± 1.2 | 23.9 ± 1.2 | 21.8 ± 2.3 |
| Po c | 24.5 ± 1.0 | 27.8 ± 1.7 | ** 22.3 ± 1.4 | 23.7 ± 1.2 | 25.0 ± 1.4 | 23.3 ± 2.1 |
| VP i | 8.4 ± 1.1 | ## 13.2 ± 1.2 | 9.5 ± 1.1 | 11.1 ± 1.3 | 10.0 ± 1.2 | 8.2 ± 1.8 |
| VP c | 9.3 ± 1.0 | 12.3 ± 0.9 | * 9.2 ± 1.1 | 10.1 ± 1.3 | 11.0 ± 1.2 | 8.5 ± 1.7 |
| AMY i | -9.3 ± 1.2 | -11.3 ± 1.3 | * -7.9 ± 1.2 | -10.9 ± 0.9 | -13.0 ± 1.4 | -10.4 ± 0.9 |
| AMY c | -5.3 ± 1.2 | # -7.0 ± 1.1 | -5.8 ± 1.4 | -8.1 ± 0.6 | -10.0 ± 1.3 | -9.3 ± 1.0 |
| Cb vermis | 4.7 ± 1.7 | ## 12.0 ± 1.2 | ** 6.9 ± 1.2 | 5.2 ± 1.7 | 5.6 ± 1.7 | 7.2 ± 2.0 |
Post-surgery (SNI) compared to pre-surgery (Naïve) by the one-way repeated measures ANOVA, #P < 0.05, ##P < 0.01. Gabapentin treatment (GBP) compared to post-surgery by the one-way repeated measures ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001. i: ipsilateral; c: contralateral. Data were presented as mean ± SEM. Abbreviations refer to the main text.