Table 3.
Hazard risk of mortality associated with age at diagnosis in pediatric ALL patients (1973–2009 SEER dataset) in an adjusted multivariable Cox proportional hazard model, stratified by the year of diagnosis.
| Variable | Model without immunophenotype | Model with immunophenotype | ||||
|---|---|---|---|---|---|---|
| Adjusted hazard ratio (AHR) | 95% C.I.* | P | Adjusted hazard ratio (AHR) | 95% C.I. | P | |
| Age at diagnosis (yr) | ||||||
| <1 | 1 | — | Reference | 1 | — | Reference |
| 1–4 | 0.18 | 0.15, 0.20 | <0.0001 | 0.13 | 0.10, 0.16 | <0.0001 |
| 5–9 | 0.25 | 0.22, 0.29 | <0.0001 | 0.20 | 0.16, 0.26 | <0.0001 |
| 10–14 | 0.43 | 0.37, 0.50 | <0.0001 | 0.37 | 0.29, 0.46 | <0.0001 |
| 15–19 | 0.68 | 0.59, 0.79 | <0.0001 | 0.60 | 0.48, 0.75 | <0.0001 |
| Sex | ||||||
| Female | 1 | — | Reference | 1 | — | Reference |
| Male | 1.25 | 1.16, 1.34 | <0.0001 | 1.23 | 1.09, 1.38 | 0.0004 |
| Race | ||||||
| Caucasian | 1 | — | Reference | 1 | — | Reference |
| AA | 1.44 | 1.27, 1.62 | <0.0001 | 1.33 | 1.10, 1.61 | 0.003 |
| Primary tumor sites | ||||||
| 1 | 1 | — | Reference | 1 | — | Reference |
| ≥2 | 0.86 | 0.67, 1.11 | 0.25 | 1.45 | 0.94, 2.23 | 0.09 |
| Radiation | ||||||
| No | 1 | — | Reference | 1 | — | Reference |
| Yes | 0.94 | 0.87, 1.03 | 0.15 | 1.02 | 0.89, 1.18 | 0.77 |
| Immunophenotype | ||||||
| T-cell | — | — | — | 1 | — | Reference |
| B-cell, B-precursor | — | — | — | 0.84 | 0.73, 0.96 | 0.01 |
*C.I.: confidence interval.