Table 1.

Effects of sclerotial extracts of L. rhinocerotis cultivar TM02 on carrageenan induced paw edema in rats

Group	Dose (mg/kg body weight)	Paw edema volume (ml)
		1 st hour	2 nd hour	3 rd hour	4 th hour	5 th hour
Control		0.28 ± 0.02	0.76 ± 0.04	0.85 ± 0.03	0.90 ± 0.04	0.86 ± 0.04
CWE TM02	25	0.25 ± 0.02 (12)	0.52 ± 0.04* (32)	0.70 ± 0.03 (18)	0.70 ± 0.03* (22)	0.65 ± 0.04* (25)
	50	0.18 ± 0.02 (36)	0.40 ± 0.07* (48)	0.50 ± 0.06* (42)	0.51 ± 0.05* (44)	0.46 ± 0.05* (47)
	100	0.18 ± 0.01 (35)	0.22 ± 0.04* (71)	0.33 ± 0.04* (62)	0.41 ± 0.03* (55)	0.35 ± 0.02* (60)
	200	0.11 ± 0.03* (61)	0.13 ± 0.03* (83)	0.10 ± 0.03* (88)	0.11 ± 0.03* (88)	0.10 ± 0.03* (89)
HMW	53**	0.11 ± 0.02* (63)	0.12 ± 0.02* (84)	0.12 ± 0.02* (86)	0.09 ± 0.02* (90)	0.08 ± 0.02* (91)
MMW	35**	0.16 ± 0.03* (44)	0.30 ± 0.04* (61)	0.35 ± 0.05* (65)	0.51 ± 0.05* (43)	0.44 ± 0.03* (49)
LMW	112**	0.23 ± 0.03 (20)	0.46 ± 0.05* (39)	0.51 ± 0.05* (41)	0.51 ± 0.04* (43)	0.47 ± 0.04* (46)
ME TM02	200	0.24 ± 0.05 (15)	0.68 ± 0.04 (11)	0.78 ± 0.04 (9.0)	0.73 ± 0.04* (19)	0.69 ± 0.03* (20)
HWE TM02	200	0.20 ± 0.03 (31)	0.41 ± 0.06* (46)	0.50 ± 0.05* (42)	0.49 ± 0.04* (46)	0.47 ± 0.03* (45)
Indomethacin	10	0.18 ± 0.03 (35)	0.23 ± 0.03* (69)	0.26 ± 0.03* (69)	0.37 ± 0.03* (59)	0.34 ± 0.03*(57)

Each value is mean ± S.E.M of six rats. *p < 0.05, compared with control using Dunnett’s t (two-sided) test. Values given in parentheses represent the percentage inhibition of edema volume at each hour as compared to the control group. **Amount isolated from 200 mg/kg of CWE TM02 using sephadex G-50 gel filtration chromatography. CWE-cold water extract; HWE-hot water extract; ME-methanol extract; HMW-high molecular weight fraction; MMW-medium molecular weight fraction; LMW-low molecular weight fraction.