Table 2.
Multivariable adjusted associations between bolus versus maintenance (Referent) dosing and study outcome (N=48,050)
| Outcome | Effect measure 1 | Estimate (95% CI) |
|---|---|---|
| Death from any cause | Hazard Ratio | 0.92 (0.79, 1.06) |
| Rate Difference | -16 (-42, 13) | |
| Infection Outcomes | ||
| Hospitalized for pneumonia, sepsis, vascular access infection | Hazard Ratio | 1.08 (0.96, 1.21) |
| Rate Difference | 21 (-9.2, 54) | |
| Hospitalized for infection of any major organ system | Hazard Ratio | 1.13 (1.03, 1.24) |
| Rate Difference | 59 (19, 106) | |
| Use of intravenous antibiotics | Hazard Ratio | 1.08 (1.02, 1.15) |
| Rate Difference | 72 (9.1, 135) | |
| Infection-Related Death | Hazard Ratio | 1.17 (0.80, 1.71) |
| Rate Difference | 3.9 (-5.1, 14) | |
| Hospitalized for pneumonia, vascular access infection, sepsis or infection-related death | Hazard Ratio | 1.08 (0.96, 1.21) |
| Rate Difference | 23 (-9.5, 56) | |
| Hospitalized for any infection or use of intravenous antibiotics | Hazard Ratio | 1.08 (1.02, 1.15) |
| Rate Difference | 107 (28, 187) | |
| Cardiovascular Outcomes | ||
| Hospitalized for stroke | Hazard Ratio | 1.07 (0.77, 1.47) |
| Rate Difference | 1.7 (-10, 15) | |
| Hospitalized for Myocardial Infarction | Hazard Ratio | 0.95 (0.69, 1.32) |
| Rate Difference | -1.7 (-13, 10) | |
| Cardiovascular-related death | Hazard Ratio | 0.82 (0.66, 1.02) |
| Rate Difference | -14 (-31, 0.97) | |
| Cardiovascular-related hospitalization or death | Hazard Ratio | 0.92 (0.78, 1.09) |
| Rate Difference | -11 (-35, 13) |
1Rate difference per 1000 patient years.