Table 4.
Descriptive characteristics of ovarian cancer cases and controls, the African American Cancer Epidemiology Study (AACES), 2010-14†
| Variable | Cases (N = 371) | Controls (N = 622) | ||||
|---|---|---|---|---|---|---|
| N (%) | N (%) | OR* | (95% CI) | OR** | (95% CI) | |
| Age group (years) | ||||||
| 20-39 | 23 (6.2) | 77 (12.4) | ||||
| 40-49 | 61 (16.4) | 115 (18.5) | ||||
| 50-59 | 131 (35.3) | 219 (35.2) | ||||
| 60-69 | 97 (26.1) | 157 (25.2) | ||||
| 70-79 | 59 (15.9) | 54 (8.7) | ||||
| Age at menarche (years) | ||||||
| <12 | 83 (22.4) | 167 (26.8) | 1.00 | Referent) | 1.00 | Referent |
| 12-13 | 186 (50.1) | 300 (48.2) | 1.22 | (0.88-1.69) | 1.30 | (0.93-1.80) |
| 13+ | 102 (27.5) | 155 (24.9) | 1.27 | (0.88-1.84) | 1.35 | (0.93-1.97) |
| Parity | ||||||
| 0 | 67 (18.1) | 83 (13.3) | 1.00 | Referent | 1.00 | Referent |
| 1-2 | 159 (42.9) | 284 (45.7) | 0.66 | (0.45-0.97) | 0.69 | (0.47-1.01) |
| >3 | 145 (39.1) | 255 (41.0) | 0.61 | (0.41-0.90) | 0.61 | (0.41-0.91) |
| Tubal ligation | ||||||
| No | 235 (63.5) | 375 (60.4) | 1.00 | Referent | 1.00 | Referent |
| Yes | 135 (36.5) | 246 (39.6) | 0.84 | (0.64-1.10) | 0.96 | (0.71-1.28) |
| Missing | 1 | 1 | ||||
| Oral contraceptive use (months) | ||||||
| Never to <3 | 129 (34.8) | 145 (23.3) | 1.00 | Referent | 1.00 | Referent |
| 3- < 36 | 102 (27.5) | 192 (30.9) | 0.64 | (0.46-0.91) | 0.66 | (0.47-0.93) |
| 36 < -60 | 31 (8.4) | 67 (10.8) | 0.54 | (0.33-0.89) | 0.55 | (0.33-0.90) |
| 60+ | 109 (29.4) | 218 (35.0) | 0.58 | (0.42-0.82) | 0.58 | (0.41-0.82) |
| Menopausal status | ||||||
| Post-menopausal | 266 (72.3) | 410 (66.2) | 1.00 | Referent | 1.00 | Referent |
| Pre-menopausal | 102 (27.7) | 209 (33.8) | 1.21 | (0.78-1.89) | 1.23 | (0.78-1.92) |
| Missing | 3 | 3 | ||||
| Hysterectomy | ||||||
| No | 279 (75.2) | 495 (79.6) | 1.00 | Referent | 1.00 | Referent |
| Yes | 92 (24.8) | 127 (20.4) | 1.12 | (0.82-1.54) | 1.12 | (0.82-1.55) |
| Use of hormone replacement therapy among women over age > =50 | ||||||
| No | 216 (75.8) | 341 (79.7) | 1.00 | Referent | 1.00 | Referent |
| Yes | 69 (24.2) | 87 (20.3) | 1.17 | (0.81-1.69) | 1.25 | (0.86-1.82) |
| Missing | 2 | 2 | ||||
| First degree relative with ovarian cancer | ||||||
| No | 340 (94.7) | 578 (96.8) | 1.00 | Referent | 1.00 | Referent |
| Yes | 19 (5.3) | 19 (3.2) | 1.57 | (0.82-3.03) | 1.60 | (0.82-3.12) |
| Missing | 12 | 25 | ||||
| First degree relative with breast cancer | ||||||
| No | 281 (77.6) | 506 (84.2) | 1.00 | Referent | 1.00 | Referent |
| Yes | 81 (22.4) | 95 (15.8) | 1.46 | (1.04-2.04) | 1.50 | (1.07-2.11) |
| Missing | 9 | 21 | ||||
| First degree relative with ovarian and/or breast cancer | ||||||
| No | 267 (73.8) | 491 (81.7) | 1.00 | Referent | 1.00 | Referent |
| Yes | 95 (26.2) | 110 (18.3) | 1.50 | (1.09-2.06) | 1.53 | (1.11-2.11) |
| Missing | 9 | 21 | ||||
| Body mass index 1 year before diagnosis (kg/m 2 ) | ||||||
| <24.9 | 54 (14.6) | 119 (19.2) | 1.00 | Referent | 1.00 | Referent |
| 25–29.9 | 95 (25.7) | 157 (25.3) | 1.24 | (0.82-1.88) | 1.31 | (0.86-1.99) |
| 30–34.9 | 107 (29.0) | 157 (25.3) | 1.49 | (0.99-2.24) | 1.50 | (0.99-2.27) |
| > = 35 | 113 (30.6) | 188 (30.3) | 1.29 | (0.86-1.92) | 1.27 | (0.85-1.91) |
| Missing | 2 | 1 | ||||
| Education | ||||||
| High school or less | 173 (46.6) | 223 (35.9) | 1.00 | Referent | 1.00 | Referent |
| Some post-high school training | 115 (31.0) | 227 (36.6) | 0.69 | (0.51-0.93) | 0.69 | (0.51-0.95) |
| College or graduate degree | 83 (22.4) | 171 (27.5) | 0.66 | (0.48-0.93) | 0.66 | (0.46-0.95) |
| Missing | 1 | |||||
| Annual Income | ||||||
| < $10,000 | 85 (23.4) | 130 (21.2) | 1.00 | Referent | 1.00 | Referent |
| $10,000 - < $25,000 | 98 (26.9) | 145 (23.6) | 1.00 | (0.68-1.46) | 1.04 | (0.71-1.53) |
| $25,000 - < $50,000 | 88 (24.2) | 131 (21.3) | 1.04 | (0.71-1.54) | 1.08 | (0.72-1.60) |
| $50,000 - < $75.000 | 48 (13.2) | 103 (16.8) | 0.72 | (0.46-1.12) | 0.75 | (0.48-1.19) |
| ≥$75,000 | 45 (12.4) | 105 (17.1) | 0.66 | (0.42-1.04) | 0.73 | (0.46-1.17) |
| Missing | 7 | 8 | ||||
| Private Physician | ||||||
| No | 104 (29.1) | 158 (26.2) | 1.00 | Referent | 1.00 | Referent |
| Yes | 253 (70.9) | 445 (73.8) | 0.77 | (0.57-1.03) | 0.77 | (0.57-1.05) |
| Missing | 14 | 19 | ||||
| Current Insurance | ||||||
| None | 41 (11.1) | 76 (12.3) | 1.00 | Referent | 1.00 | Referent |
| Medicaid | 97 (26.1) | 124 (20.0) | 1.37 | (0.86-2.20) | 1.38 | (0.85-2.22) |
| Medicare | 96 (25.9) | 128 (20.6) | 1.04 | (0.63-1.74) | 1.03 | (0.61-1.72) |
| Other Insurance | 137 (36.9) | 292 (47.1) | 0.84 | (0.54-1.29) | 0.86 | (0.56-1.34) |
| Missing | 0 | 2 | ||||
| Ever smoked | ||||||
| Current/Former | 163 (43.9) | 259 (41.6) | 1.00 | Referent | 1.00 | Referent |
| Never | 208 (56.1) | 363 (58.4) | 0.97 | (0.75-1.27) | 1.00 | (0.76-1.30) |
†Forty-nine patients (32 cases and 17 controls) were excluded from this table due to missing data for either parity or months of oral contraceptive use.
OR = Odds Ratio, CI = Confidence Interval.
*Age adjusted(ORs).
**Multivariable adjusted (ORs) adjusted for age, months of oral contraceptive use, and parity.