Table 3.
Estimated sensitivity and specificity of different optic coherence tomography measures for retinal thickness changes detection in eyes of patients with relapsing-remitting multiple sclerosis (N = 140) and from healthy control subjects (N = 140) using latent class analysis. Model A: temporal pRNFL thickness as measured by Cirrus OCT; estimated prevalence of retinal thickness changes in the sample was 23.42%; 95% confidence interval (95CI) 18.50 to 29.17%. Model B: temporal pRNFL thickness as measured by Spectralis OCT; estimated prevalence of retinal thickness changes in the sample was 24.25%; 95% confidence interval (95CI) 19.26 to 30.04%.
| Sensitivity | Specificity | |||
|---|---|---|---|---|
| Estimate | 95CI | Estimate | 95CI | |
| Model A | ||||
| Cirrus average GCIPL | 96.34% | 76.11 to 99.54% | 97.05% | 92.77 to 98.83% |
| Cirrus minimum GCIPL | 98.43% | 64.61 to 99.95% | 95.81% | 91.00 to 98.10% |
| Cirrus temporal pRNFL | 58.41% | 45.82 to 70.00% | 93.91% | 89.56 to 96.52% |
| Best corrected visual acuity | 6.14% | 2.32 to 15.30% | 98.59% | 95.72 to 99.54% |
| Model B | ||||
| Cirrus average GCIPL | 97.15% | 76.94 to 99.71% | 97.61% | 93.16 to 99.19% |
| Cirrus minimum GCIPL | 96.41% | 81.48 to 99.39% | 95.43% | 90.80 to 97.78% |
| Spectralis temporal pRNFL | 69.69% | 57.14 to 79.86% | 92.70% | 88.01 to 95.65% |
| Best corrected visual acuity | 6.08% | 2.30 to 15.15% | 98.55% | 95.58 to 99.53% |
GCIPL: ganglion cell-inner plexiform layers; pRNFL: peripapillary retinal nerve fiber layer.