Figure 2. Cardiac dysfunction in norepinephrine administrated mice.

(A) Morphological characteristics of isolated heart from control group and norepinephrine administrated group. Histological evaluation the cross-sectional area of heart tissue from normal group (B), norepinephrine administrated mice (C), Magnification=200×. (D) Norepinephrine administration increased the cross-sectional area compared with control, *P<0.05. (E) Ratio of HW/BW within two group,*P<0.05. (F) The mRNA level of IGF1R, β-MHC, ANP were up-regulated in norepinephrine administrated heart tissues, *P<0.05 versus control. Echocardiographic evaluation of heart function in normal mice (G) and hypertrophic heart (H). (I) Norepinephrine administration decreased the fractional shortening of left ventricle (FS%) and EF%,*P<0.05 versus control. (J) Norepinephrine administration induced cardiac hypertrophy. Parameters of cardiac hypertrophy were evaluated, *P<0.05 versus control. LVDd;d, diastolic left ventricle internal dimension; LVDd;s, left ventricular diastolic dimension