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. 2014 Oct 2;34(5):e00140. doi: 10.1042/BSR20130107

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© 2014 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) Morphological characteristics of isolated heart from different groups. (B) Ratio of HW/BW in different group,*P<0.05. Histological evaluation the cross-sectional area of heart tissue from normal group (C), shIGF1R administrated group (D), saline-treated group (E), Magnification=200×. (F) shIGF1R administration attenuated the cross-sectional area compared with control, *P<0.05. Echocardiographic evaluation of heart function in normal mice (G), hypertrophy (H), shIGF1R-treated mice (I). (J) shIGF1R administration increased the fractional shortening of left ventricle (FS%) and EF%,*P<0.05 versus control. (K) Parameters of cardiac hypertrophy:LVDd;d, diastolic left ventricle internal dimension; LVDd;s were evaluated, *P<0.05 versus control.