. Author manuscript; available in PMC: 2014 Oct 2.

Published in final edited form as: J Med Chem. 2008 Sep 25;51(18):5608–5616. doi: 10.1021/jm800329z

Table 2.

Enantiomer composition (%) of [¹¹C]12a after treating (-)-12b, (-)-12c or (+)-12c with [¹¹C]cyanide ion in DMSO the presence of various bases

Precursor	Base (a)	[¹¹C](-)-12a (%)	[¹¹C](+)-12a (%)
(-)-12b	KOH, K2.2.2	50	50
	NaHCO₃	90	10
(-)-12c	NaOAc	50	50
	NaHCO₃	90	10
	KH₂PO₄	> 97 (n = 4)	< 3 (n = 4)
(+)-12c	KH₂PO₄	< 3 (n = 1)	> 97 (n = 1)