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. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: Open Pain J. 2013;6(Spec Iss 1):119–126. doi: 10.2174/1876386301306010119

Figure 1. Schematics of activation, regulation and functions of transient receptor potential vanilloid subtype 3 (TRPV3) in keratinocytes.

Figure 1

Chemical and thermal agonists activate TRPV3 in keratinocytes. G-protein coupled receptors (GPCR), receptor tyrosine kinase (RTK), and other intracellular factors modulate the functions of TRPV3. TRPV3 activation induces the release of potential signaling molecules such as prostaglandins and cytokines. See text for references. 2-APB, 2-aminoethyl diphenylborinate; AA, arachidonic acid; ATP, adenosine triphosphate; CaM, calmodulin; EGF, epidermal growth factor; FPP, farnesyl pyrophosphate; IL-1 α, interleukin 1α; NO, nitric oxide; PGE2, prostaglandin E2; PIP2, phosphatidylinositol (4,5) bisphosphate; PKC, protein kinase C; PLC, phospholipase C; TGF-β, transforming growth factor-β.