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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Cancer Res. 2014 Jul 31;74(18):5057–5069. doi: 10.1158/0008-5472.CAN-13-3723

Figure 6. CSF1/CSF1R signaling blockade elevates PDL1 expression in tumor cells.

Figure 6

A–B) qRT-PCR analysis of KI tumors following 8-day treatment with vehicle, CSF1Ri or αCSF1.

C) PDL1 and PDL2 expression in denoted tumor-infiltrating myeloid cells from orthotopic KI tumors treated with vehicle or CSF1Ri. Representative FACS plots and MFI are depicted.

D) Mean percentage of PDL1+ and PDL2+ TAMs and monocytes.

E) Mean percentage of PDL1+ PDAC cells in orthotopic KI tumors from mice treated with vehicle, CSF1Ri, or αCSF1. PDAC cells were identified as CD45− mCherry+.

F–G) PD1 expression in tumor-infiltrating myeloid cells following vehicle or CSF1Ri treatment. Representative expression plots, MFI and positive cells percentage data are depicted.

All graphs depict means values +/−SEM, n=3–7 mice/group. * denotes p<0.05 by unpaired t-test.