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. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: J Trauma Acute Care Surg. 2013 Feb;74(2):499–507. doi: 10.1097/TA.0b013e31827d5db2

Figure 3.

Figure 3

Effects of bortezomib in a Wiggers model of sublethal hemorrhagic shock and resuscitation. Black symbols, bortezomib group (n = 5). Open symbols, vehicle group (n = 5). Data are presented as mean (SD). The arrows indicate the time point of bortezomib/vehicle administration. A, Blood volume (BV) hemorrhaged (mL/kg) to achieve a MAP of 30 mm Hg for 30 minutes (circles) and MAP (mm Hg; squares). B, Resuscitation fluid requirements (mL/kg) to maintain MAP of 70 mm Hg (circles) and arterial blood lactate levels (mmol/L; squares). C, CT-L proteasome peptidase activates in heart (open bars), lung (light grey bars), and pectoral muscle (dark grey bars) extracts in % of the vehicle group (100%). *p < 0.05 versus vehicle group.