Table IV.
Summary of AEs Relateda to Hypertension Medications
| Aggressive Group | Standard Group | P Value b | |
|---|---|---|---|
| Participants with ≥1 AE, % | 25.0 (19.9–30.1)c | 14.3 (10.2–18.5) | .002 |
| No. of AEs | 118 | 54 | <.001 |
| Most common AEs | |||
| Dizziness (lisinopril, atenolol, amlodipine, HCTZ, valsartan)d | 41 (34.8%)e | 9 (16.7%)e | |
| Cough or nonproductive cough (lisinopril, enalapril)d | 13 (11.0%) | 15 (27.8%) | |
| Fatigue (lisinopril, atenolol, HCTZ, doxazosin)d | 13 (11.0%) | 3 (5.6%) | |
| Occurrences of orthostatic hypotension, No. | 2 | 3 | |
| Drugs reported most often | |||
| Lisinopril (cough, dizziness)f | 40 (33.9%)e | 19 (35.2%)e | |
| Atenolol (dizziness, bradycardia, fatigue)f | 21 (17.8%) | 7 (13.0%) | |
| HCTZ (dizziness, nausea, fatigue)f | 17 (14.4%) | 10 (18.5%) | |
| Amlodipine (dizziness, edema)f | 10 (8.5%) | 5 (9.3%) | |
| Drugs with highest incidence of AEs (AEs/100 person‐years) | |||
| Atenolol | 8.86 (5.24–12.48) | 4.52 (1.25–7.79) | .1 |
| Lisinopril | 6.15 (4.30–8.00) | 4.44 (2.49–6.39) | .2 |
| Amlodipine | 5.13 (2.03–8.23) | 4.57 (0.66–8.48) | .8 |
| HCTZ | 4.12 (2.20–6.04) | 4.30 (1.69–6.91) | .9 |
Abbreviations: AEs, adverse events; HCTZ, hydrochlorothiazide. aPossibly, probably, or definitely related. bChi‐square test was used to calculate the P value. cNumbers in parentheses are 95% confidence interval for percentages. dMost frequently reported drugs. eNumber in parentheses is percentage of total AEs for group. fMost frequently reported AEs.