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. 2014 Oct 2;6:266. doi: 10.3389/fnagi.2014.00266

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Copyright © 2014 Acosta-Cabronero and Nestor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TBSS in AD. TBSS results for N = 43 early-stage AD patients (age: 70 ± 6, <MMSE > = 24 ± 4) vs. N = 26 matched controls (age: 68 ± 6) (Acosta-Cabronero et al., 2012). Pink clusters denote increased MD in patients, whereas those in yellow represent FA reductions at P < 0.05 enabling threshold free cluster enhancement (TFCE) (Smith and Nichols, 2009) and controlling the family-wise error (FWE) rate. Thresholded statistical maps are overlaid onto the TBSS skeleton and MNI152 template. Sagittal MNI coordinates are given in millimeter where x < 0 is left. Abbreviations: [SLF] superior longitudinal fasciculus; [SS] sagittal stratum; [CR] corona radiata; [s/b/gCC] splenium/body/genu of the corpus callosum; [CGc/h] cingulum at the level of the posterior cingulate/parahippocampus; and [FX] fornix.