DTI ACQUISITION |
✓ Number of diffusion-encoding directions equal to or greater than 30 |
✓ Quasi-isometric voxels—ratio between in-plane resolution and slice thickness greater than 0.75, i.e., the geometry of 1.875 × 1.875 × 2.5 mm3 voxels is at the lower limit |
✓ Voxels smaller than 20 mm3, i.e., image resolution 2.7 × 2.7 × 2.7 mm3 is at the upper limit |
✓ Maximum b-value equal to or greater than 900 s/mm2
|
STUDY COHORT |
✓ (i) Clinical diagnosis of probable AD (at acquisition or through clinical follow-up), (ii) positive CSF analysis for AD (iii) positive amyloid-PET, or (iv) autosomal dominantly inherited mutation carriers |
✓ Number of subjects equal or greater than N = 10 in each group |
DATA ANALYSIS |
✓ Voxel-/cluster-wise (or region-average) whole-brain TBSS |
✓ Show results for both FA and MD (at least) |
✓ Demonstrate results are robust against multiple testing effects |
Desirable (additional suggested criteria for future studies) |
DTI ACQUISITION |
+ Studies performed on a single scanner |
+ Use of multiple b-values, i.e., Nb≥ 2 |
+ If Nb = 1, total number of measurements greater than 60, i.e., Nm > 60 |
+ Ensure stable S0 measurement, i.e., Nb0 ≥ 5 |
+ Voxels equal to or smaller than 8 mm3, i.e., image resolution 2 × 2 × 2 mm3 or finer |
+ Perfect voxel symmetry (or within 90%) |
DATA ANALYSIS |
+ Avoidance of RS-TBSS pipelines |