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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Nat Immunol. 2014 Jul 27;15(9):856–865. doi: 10.1038/ni.2947

Fig. 7. A fraction of tonsillar TFH cells co-express RORγt.

Fig. 7

(a) Bcl-6 and RORγt expression by ex vivo tonsillar GC TFH cells and naïve TH cells was analyzed by flow cytometry. A representative of 4 independent experiments. (b) Expression of CXCR5 and ICOS by ex vivo tonsillar Bcl-6+RORγt−,Bcl-6+RORγt+ and Bcl-6−RORγt+ TH cells (defined as shown in the left panel). The red dots indicate the expression of CXCR5 and ICOS by the cells with the indicated transcription factor expression pattern. The global tonsillar TH cells are indicated by gray dots. A representative out of 5 independent experiments. (c) Human tonsil sections were stained for IgD (indicated by red), CD4 (indicated by blue), and RORγt (indicated by green), and analyzed by confocal microscopy. GC: germinal center. MZ: mantle zone. Representative RORγt+ TH cells in GCs are shown in panel (d).