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. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: Microrna Diagn Ther. 2013 Apr 26;1(1):2013-0001. doi: 10.2478/micrnat-2013-0001

Figure 1. An internal bulge is critical for the functionality of miRNA mimicking sequences.

Figure 1

RNA duplexes that include a bulged structure, but not siRNA-like preparations, recapitulate the activity of endogenous miRNAs. A hypothetical model explaining these differential effects is depicted.