TABLE 1.
MPL-regulated probe sets related to transcription-translation
| 230A probe set | 230A accession | U34A probe set/accession | Symbol | Identification | Response
|
|
|---|---|---|---|---|---|---|
| Acute | Chronic | |||||
| 1387947 | U56241 | U56241 | Mafb | Transcription factor Maf1 | Up | Up |
| 1387870 | AB025017 | X63369 | TIS11 | Transcription factor (immediate early gene) | Up | Up |
| 1386910 | AF311054 | D44495 | Apex | Apurnic Endonuclease (DNA repair) | Up | Up |
| 1371987 | BI274697 | AA891891 | DNA repair | Polymerase (DNA directed) sigma (DNA repair) | Up | Up |
| 1367601, 1367602 | NM_053698 | AA900476 (2), AI014091 | Cited2 | Cbp/p300-interacting transactivator | Up | Up |
| 1387779 | NM_031668 | AI237258, AI229637 | Mybbp1a | MYB binding protein (P160) 1a | Up | Up |
| 1368308 | NM_012603 | Y00396 (2) | Myc | Myelocytomatosis proto-oncogene | Up | Up |
| 1367831 | NM_030989 | X13058 | Tp53 | Tumor protein p53, p53 tumor sUppressor | Up | Up |
| 1389508, 1374404 | BI288619 | AA944014 | v-jun Sarcoma virus 17 oncogene | Up | Up | |
| 1389521 | AI408553 | AA799539 | IVNS1ABP | Influenza virus NS1A binding protein | Up | Up |
| 1392633 | BE105480 | AA946439 | H4 | Histone H4 | Up | Up |
| 1371872, 1370826, 1373473 | BM386384 | AF062594 (2), AA859920, AA866472 | Nap1l1 | Nucleosome assembly protein 1-like 1 | Up | Up |
| 1372242, 1375901 | AI169598 | U21719 | Ddx3x | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, helicase (RNA) | Up | Up |
| 1368031, 1368032, 1368033 | NM_022869 | AA998882, M94287 | Nopp140, Nolc1 | Nucleolar phosphoprotein 140, interacts with RNA pol | Up | Up |
| 1388321 | BG378108 | AA799369 | IMP3 | U3 small nucleolar ribonucleoprotein (ribosome biogenesis) | Up | Up |
| 1368867 | BF281131 | H31692 | EIF2C1, GERP95 | Translation initiation factor 2C | Up | Up |
| 1388576 | BF281368 | AA875205 (2) | EIF3 | Translation initiation factor 3 | Up | Up |
| 1372090 | AI231566 | D14448 | Max | Myc family DNA-binding protein, leucine zipper | Up | Up |
| 1388779, 1387962 | U41164, BG381516 | U41164 | rKr1, Zfp180 | Cys2/His2 zinc finger protein (Kruppel family) | Up | Up |
| 1373012, 1373011 | BE109520 (2) | AA894086 | Zfp622 | Zinc finger protein 622 | Up | Up |
| 1371864, 1370209 | BE101336, AW524563 | D12769 | Bteb1 | Klf9, Basic transcription element binding protein 1 | Up | Up |
| 1387714, 1369737, 1369738 | AB031423, NM_017334 (2) | S66024 | CREM | Transcriptional repressor, cAMP-responsive element | Up | Up |
| 1371781 | BI285863 | AI639141, X91810 | Stat3 | Signal transducer and activator of transcription 3 | Up | Up |
| 1371714 | BG378760 | AA893885 | Foxk2 | Forkhead box K2 | Up | Up |
| 1371489 | AI011748 | AF022081 | Rnf4 | Small nuclear RING finger protein | Up | Up |
| 1370510 | AB012600 | AF015953 | ARNTL, BMAL1b | BMAL1b, aryl hydrocarbon receptor nuclear translocator-like | Up | Up |
| 1370309 | AJ238854 | AB016536 | alf-c1 | Heterogeneous nuclear ribonucleoprotein type A/B | Up/down | Up |
| 1370474, 1370474 | J03933 | J03819 | Thrb, (c-erbA-β) | Rat thyroid receptor hormone β | Down/up | Up |
| 1387365 | NM_031627 | U11685 | Nr1h3 | Liver X receptor, α | Down/up | Up |
| 1372876 | AA799700 | AA799700 | SPS2 | Selenophosphate synthetase 2 | Down/up | Up |
| 1369679 | AB060652 | D78018, × 13167 | NFI-A | Transcription factor nuclear factor1-A1 | Down/up | Up |
| 1369834 | NM_012742 | X55955 | Hnf3a, Foxa1 | Hepatocyte nuclear factor 3-α Forkhead box A1 | Down | Up |
| 1375428 | BE099979 | AA858607 | Creg1 | Repressor of E1A-stimulated genes (cell growth and differentiation) | Down | Up |
| 1376196 | BG375059 | AA800290 | D receptor interacting protein | Down | Down | |
| 1389601, 1373644 | BI293610 | AA859994 | Nfib | Nuclear factor I/B | Down | Down |
| 1387769 | AF000942 | AI171268, AF000942 | Id3 | DNA binding protein inhibitor 3 BHLH | Down | Down |
| 1368712 | NM_019620 | U67082 | Kzf1 | Zinc finger protein 386 (Kruppel-like) | Down | Down |
| 1369959 | NM_017172 | AI136891, AI112516 | Zfp36l1 | Zinc finger protein 36, C3H type-like 1, Kruppel Type 18 | Down | Down |
| 1368711 | NM_012743 | L09647 | Hnf3b, Foxa2 | Forkhead box A2 | Down | Down |
| 1373837 | BI296633 | AI227715 | Rbl2 | Retinoblastoma-like 2 (p130) | Down | Down |
| 1369063 | NM_012903 | AA875495, D32209, | Anp32 | Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | Down | Down |
| 1367826 | NM_031789 | AI177161 | NF-E2-related factor 2 | Nuclear factor erythroid 2-like 2 | Down | Down |
| 1388650 | BM385445 | AA899854 | Top2a | Topoisomerase (DNA) 2α | Down | Down |
| 1372889 | AI407489 | M64862, AA800797 | DNA-binding protein; matrin F/G | Down | Down | |
| 1367759 | NM_012578 | AI232374 | H1f0 | Histone H1–0 | Down | Down |
| 1370381 | U61729 | U61729 | Prol2 | Proline rich 2 | Up/down | Down |
| 1368376 | NM_057133 | D86580 | Nr0b2 | Small heterodimer partner; SHP; SHP1 | Up/down | Down |
| 1374752 | AI408734 | AI639149 | Mdfic | MyoD family inhibitor domain containing | Up/down | Down |
| 1398756,1398757, 1398758 | NM_012992 | J03969, J04943 | Npm1 | Nucleophosmin 1, nuclear protein B23 | Up | Down |
| 1398832 | NM_012749 | M55015, M55017 | Ncl | Nucleolin | Up | Down |
| 1370711 | AF000900 | U63839, AF000899, AF000901 | p58/p45 | Nucleoporin p58 | Up | Down |
| 1387028 | M86708 | L23148 | Id1 | DNA-binding protein inhibitor 1 BHLH | Up | Down |
| 1372757, 1368835, 1387354 | BM386875 | AA892553 | Stat1 | Activator of transcription 1 | Up | Down |
| 1386897 | NM_024363 | U60882 | Hrmt1l2 | Heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 | Up/down | Up/down |
| 1368303 | NM_031678 | AB016532 | Per2 | Period homolog 2 | Oscillating | Oscillating |
Probe sets regulated by MPL in rat liver after both acute and chronic drug administration and categorized as relating to either transcription or translation. Affymetrix 230A arrays use a probe set number distinct from GenBank accession numbers, whereas U34A chips use a common probe set/GenBank accession number for identification.