TABLE 3.
MPL-regulated probe sets related to small molecule metabolism
| 230A probe set | 230A accession | U34A probe set/accession | Symbol | Identification | Response
|
|
|---|---|---|---|---|---|---|
| Acute | Chronic | |||||
| 1387109 | NM_031576 | AI137856, M10068 | Por | P450 (cytochrome) oxidoreductase | Up | Up |
| 1371021, 1375412 | AI101331 | D49434 | Arsb | Arylsulfatase B, lysosomal Glycosaminoglycan degradation | Up | Up |
| 1370370 | AF034218 | AF034218 (2) | Hyal2 | Hyaluronidase 2, lysosomal glycosaminoglycan degradation | Up | Up |
| 1387963 | M24396 | J03959, × 13098 | Uricase, urate oxidase 2 | Up | Up | |
| 1387740, 1379361 | NM_053487 | AA892128, AJ224120 | Pex11a | Peroxisome biogenesis factor 11A | Down/up | Up |
| 1368180 | NM_017013 | AI235747 | Gsta2 | Glutathione-S-transferase, α-type 2 | Down/up | Up |
| 1369986 | NM_033349 | AI012802 | Hagh | Hydroxyacyl glutathione hydrolase, both cytosol and M | Down/up | Up |
| 1367798 | NM_017201 | M15185 | Ahcy | S-adenosylhomocysteine hydrolase, cytosol | Down/up | Up |
| 1370698 | M13506 | M13506 | UDPGTR-2 | Liver UDP-glucuronosyltransferase, phenobarbital-inducible, microsomal | Down/ up | Up |
| 1398307 | D38381 | D38381 | Cyp3a18 | P450 6β-2 | Down/up | Up |
| 1387314 | NM_022513 | D89375 | Sult1b1 | Sulfotransferase family 1B, member 1 cytosol | Down/up | Up |
| 1387825 | NM_031533 | J02589 | Androsterone UDP-glucuronosyltransferase | Down/up | Up | |
| 1368226 | NM_133525 | U82591 | Rcl, C6orf108 | Nucleoside 2-deoxyribosyltransferase domain (c-Myc-responsive) | Down/up | Up |
| 1387659 | AF245172 | AA859837 (2) | Gda | Guanine deaminase | Up | Down/up |
| 1387973 | U39206 | U39206 | CYP4F4 | CYP4F4 | Down | Up |
| 1387243 | K02422 | K03241 | Cyp1a2 | Cyp1a2 | Down | Up |
| 1370496 | AB008424 | AB008424 | Cyp2d3 | Cyp2d3 | Down | Up |
| 1367843 | NM_134407 | AA892821 (2) | Akr7a2, Aiar | Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), perox | Down | Up |
| 1388300 | AA892234 | AA892234 | Gst3 | Glutathione S-transferase 3, microsomal | Down | Up |
| 1368717 | NM_024132 | U72497 | Faah | Fatty acid amide hydrolase (degrades bioactive fatty acid amides) | Down | Up |
| 1387958 | L32601 | L32601 | 20 α-Hydroxysteroid dehydrogenase | Down | Up | |
| 1387672 | NM_017084 | X06150, AA893219 | Gnmt | Glycine methyltransferase | Down/up/down | Up |
| 1371076 | AI454613 | K01721 | Cyp2b15 | Cyp2b15 | Down/up | Down/up |
| 1368497 | NM_012833 | D86086 | Abcc2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Down/up | Down |
| 1370397 | M33936 | AA924591 | Cyp4A3 | Cytochrome P450 4A3 | Up | Down |
| 1370080 | NM_012580 | J02722 | HEOXG Heox Hmox | Heme oxygenas | Up | Up/down |
| 1387916 | U39208 | U39208 | U39208 | CYP4F6 | Down | Down |
| 1369424 | NM_012693 | J04187 | Cyp2a2 | Cyp2a2 | Down | Down |
| 1367988 | U04733 | U04733 | cyp 2C23 | Cytochrome P450 arachidonic acid epoxygenase | Down | Down |
| 1387669 | NM_012844 | M26125 | Ephx1 | Epoxide hydrolase 1, microsomal | Down | Down |
| 1387214 | NM_031565 | X81395 | Ces1 | Carboxylesterase 1 | Down | Down |
| 1387022 | NM_022407 | AF001898 | Aldh1a1 | Aldehyde dehydrogenase family 1, member A1 cytosolic | Down | Down |
| 1369296 | NM_031732 | L22339 (2) | Sult1a2 | Sulfotransferase family, cytosolic, 1C, member 1, N-hydroxy-2-acetylaminofluorene; sulfotransferase | Down | Down |
| 1387221 | NM_024356 | AI639457 | Gch | GTP cyclohydrolase 1 | Down | Down |
| 1378753 | AI638971 | AI638971 | Tpmt | Thiopurine methyltransferase | Down | Down |
| 1368409 | NM_012796 | AI138143, D10026 | Gstt2 | Glutathione S-transferase, θ 2 | Down | Down |
| 1370688, 1372523, 1370030 | J05181, AA892770, NM_017305 | J05181 (3), S65555 | Glclc | Glutamate-cysteine ligase, catalytic subunit | Down | Down |
| 1368826 | NM_012531 | M93257, M60753 | Comt | Catechol-O-methyltransferase | Up/down/up | Down |
Probe sets regulated by MPL in rat liver after both acute and chronic drug administration and categorized as relating to small molecule metabolism. Affymetrix 230A arrays use a probe set number distinct from GenBank accession numbers, whereas U34A chips use a common probe set/GenBank accession number for identification.