TABLE 6.
MPL-regulated probe sets related to protein or amino acid metabolism
| 230A probe set | 230A accession | U34A probe set/accession | Symbol | Identification | Response
|
|
|---|---|---|---|---|---|---|
| Acute | Chronic | |||||
| 1386923, 1375642 | M62388 | M62388 (2), AA799612 | Ubiquitin-conjugating protein | Up | Up | |
| 1371814 | BI282191 | AA859722 | Ube2g2 | Ubiquitin-conjugating enzyme E2G 2 | Up | Up |
| 1382059 | BI289529 | AI639506 | Fbxo30 | F-box protein 30 (Fbxo30), protein-ubiquitin ligases | Up | Up |
| 1392633 | AI045724 | AI639312 | Fbxo32 | F-box only protein 32 (Fbxo32), protein-ubiquitin ligases | Up | Up |
| 1370964 | BF283456 | X12459 | Ass | Argininosuccinate synthetase (ammonia detoxification) | Up | Up |
| 1368720 | NM_022403 | AA945143 | Tdo2 | Tryptophan 2,3-dioxygenase (kynurenine pathway) | Up | Up |
| 1368247 | NM_031971 | AI170613 (2) | Hspa1a, Hsp10 | mitochondrial chaperonin | Up | Up |
| 1398960 | AI172328 | AA875047 | TCP20 | chaperonin subunit 6a (ζ) | Up | Up |
| 1388698 | AI236601 | AI236601 | HSP105 | Heat shock protein 105 | Up | Up |
| 1389021 | BF284746 | AA799531 | ASNS | Asparagine synthetase domain containing 1 | Up | Up |
| 1368188 | NM_017233 | AA866302 | Hpd | 4-Hydroxyphenylpyruvic acid dioxygenase | Down/up | Up |
| 1367695 | NM_022390 | J03481 | Qdpr | Quinoid dihydropteridine reductase (PKU) | Down/up | Up |
| 1368794 | NM_020076 | D28339, D44494 | Haao | 3-Hydroxyanthranilate 3,4-dioxygenase (synthesis of quinolinic acid) | Down/up | Up |
| 1368266 | NM_017134 | J02720 | Arg1 | Arginase 1 (ammonia detoxification) | Down/up | Up |
| 1370200, 1387878 | AI179613, AI233216 | BI284411 | Glud1 | Glutamate dehydrogenase 1(ammonia detoxification) | Down | Up |
| 1368085 | NM_133595 | U85512 | Gchfr | GTP cyclohydrolase I feedback regulator (phenylalanine, tyrosine, and tryptophan hydroxylases) | Down | Up |
| 1368092 | NM_017181 | M77694 | Fah | Fumarylacetoacetate hydrolase (tyrosinemia type I) | Down | Up |
| 1367627 | NM_031031 | U07971 | Gatm | Glycine amidinotransferase (L-arginine:glycine amidinotransferase) | Down | Down |
| 1387307 | NM_017159 | M58308, AB002393 | Hal | Histidine ammonia lyase | Down | Down |
| 1373686 | AA893495 | AA893495 | Serpina6 | Serine (or cysteine) proteinase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 6 | Down | Down |
| 1387193, 1368447, 1368446 | NM_012674 | M35299 | Spink1 | Serine protease inhibitor, Kazal type 1 | Down | Down |
| 1368280 | NM_017097 | D90404 (2) | Ctsc | Cathepsin C | Down | Down |
| 1370386 | AB002406 | AB002406 | Ruvbl1 | Ribosomal protein s25 | Up/down | Down |
| 1374255 | BI281789 | AA875602 | Phenylalanine-tRNA synthetase-like, α-subunit | Up/down | Down | |
| 1373592 | AI407094 | AA875037 | Serine proteinase inhibitor mBM2A, serine (or cysteine) peptidase inhibitor, clade B, member 9 | Up/down | Down | |
| 1373263, 1376737 | AW523737 | H31976 | SUMO | Sentrin specific protease 5 | Up | Down |
| 1367710 | NM_017257 | D45250 | Psme2 | Proteasome (prosome, macropain) 28 subunit, β | Up | Down |
| 1375421 | AI600019 | AA894089 | Neurodap1 | Neurodegeneration associated protein 1 | Up | Down |
| 1372665 | AI230228 | AI230228 | Phosphoserine aminotransferase | Up | Down | |
Probe sets regulated by MPL in rat liver after both acute and chronic drug administration and categorized as relating to protein or amino acid metabolism. Affymetrix 230A arrays use a probe set number distinct from GenBank accession numbers, whereas U34A chips use a common probe set/GenBank accession number for identification.