TABLE 7.
Nuclear-encoded mitochondrial genes regulated by MPL
| 230A probe set | 230A accession | U34A probe set/accession | Symbol | Identification | Response
|
|
|---|---|---|---|---|---|---|
| Acute | Chronic | |||||
| 1398870, 1370785 | D63411 | U21871, D63411 | TOM20 | Outer mitochondrial membrane receptor rTOM20 | Up | Up |
| 1387773 | NM_012839 | K00750 (2) | Cycs | Cytochrome c, apoptosis | Up | Up |
| 1398763, 1368051 | NM_032066 | U81186 (2) | Hsd17b12 | Translocase of inner mitochondrial membrane 23 | Up | Up |
| 1371795, 1370005 | NM_030586 | Y12517, AI232256 | omb5 | Cytochrome b5, outer mitochondrial membrane isoform | Up | Up |
| 1367982 | NM_024484 | J03190 (2) | Alas1 | Aminolevulinic acid synthase 1, heme biosynthetic | Up | Up |
| 1375504 | BM390747 | AA892950 | Polymerase (DNA), γ2, mitochondrial DNA | Up | Up | |
| 1370918 | BI275939 | L19927 | Atp5c1 | ATP synthase, H+ transporting, mitochondrial F1 complex | Down/up | Up |
| 1386917 | NM_012744 | U32314 (2) | Pc | Pyruvate carboxylase (pyruvate to oxaloacetate) | Down/up | Up |
| 1377758 | BF415386 | AA893658 | Short-chain dehydrogenase/reductase 9 | Down/up | Up | |
| 1389021 | BF284746 | AA891785 | Idh2 | Isocitrate dehydrogenase 2 | Down/up | Up |
| 1368514 | NM_013198 | M23601 | Maob | Monoamine oxidase B, mitochondria | Down/up | Up |
| 1369799 | U29701 | D87839 (2) | Abat | 4-Aminobutyrate aminotransferase, GABA amino-transferase mitochondria | Down/up | Up |
| 1370151 | NM_017072 | M11710, | Cps1 | Carbamoyl-phosphate synthetase 1, mitochondrial (ammonia detoxification) | Down/up | Up |
| 1369671 | K03040 | M11266 | Otc | Ornithine transcarbamylase mitochondria (ammonia detoxification) | Down/up | Up |
| 1370592 | AB019693 | AA893035 | HP33, Keg1 | Kidney expressed gene 1 | Down | Up |
| 1369023 | NM_031052 | M96633 | Mipep | Mitochondrial intermediate peptidase | Down | Up |
| 1368566 | AA964381 | AB000098 | Mipp65 | NADH dehydrogenase (ubiquinone) flavoprotein 3-like | Down | Up |
| 1370232 | AI102838 | J05031 | Ivd | Isovaleryl coenzyme A dehydrogenase | Down | Up |
| 1368079 | NM_053826 | L22294 | Pdk1 | Pyruvate dehydrogenase kinase 1 | Down | Up |
| 1370509 | AF062741 | AF062741(2) | Pdp2 | Pyruvate dehydrogenase phosphatase isoenzyme 2 | Down | Down |
| 1368387, 1374765 | BI288055, NM_053995 | AA817846 | BDH | 3-Hydroxybutyrate dehydrogenase mitochondrial | Down | Down |
| 1371824 | AA891949 | AA891949 | Ak4 | Adenylate kinase 4 | Down | Down |
| 1369588, 1370350 | AF368860, NM_012915 | D13122 | IF1PA | ATPase inhibitor (mitochondrial IF1 protein) | Down | Down |
Probe sets regulated by MPL in rat liver after both acute and chronic drug administration and identified as nuclear-encoded mitochondrial genes. Affymetrix 230A arrays use a probe set number distinct from GenBank accession numbers, whereas U34A chips use a common probe set/GenBank accession number for identification.