TABLE 8.
MPL-regulated probe sets related to lipid metabolism
| 230A probe set | 230A accession | U34A probe set/accession | Symbol | Identification | Response
|
|
|---|---|---|---|---|---|---|
| Acute | Chronic | |||||
| 1398272 | NM_022860 | D17809 | Galgt1 | (N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase | Up | Up |
| 1369656, 1389299 | M36071 | AA925887 | Pcyt1a | Phosphate cytidylyltransferase 1, choline, α (phosphatidylcholine synthesis) | Up | Up |
| 1368890 | NM_053410 | AA799779 (2) | Gnpat | Glyceronephosphate O-acyltransferase (bio-synthesis of ether phospholipids, peroxisomes) | Up | Up |
| 1384417 | AA998783 | AA945171 | Apoc4 | Apolipoprotein C-IV | Down | Up |
| 1369465 | NM_012584 | M67465 | Hsd3b | Steroid δ-isomerase, 3β (biosynthesis hormonal steroids) | Down | Up |
| 1368239 | NM_053541 | AB009463 | rLRp105 | Low-density lipoprotein receptor-related protein 3 | Down/up | Up |
| 1382680 | AA874941 | AA874941, AA893280 | ADRP | Adipose differentiation-related protein, | Down/up | Up |
| 1367662 | NM_031682 | AA945583 | Hsd17b10 | Hydroxyacyl-coenzyme A dehydrogenase type II (β-oxidation of fatty acids) | Down/up | Up |
| 1368232 | NM_031063 | AA924198, M29472 | Mvk | Mevalonate kinase, biosynthesis of cholesterol | Down/up | Down/up |
| 1387183 | J02844 | U26033, J02844 | CROT | Carnitine octanoyltransferase | Down | Down |
| 1370909, 1388153 | D90109, BI277523 | D90109, AI044900, AA893242 (2) | ACS COAA | Long-chain acyl-CoA synthetase | Down | Down |
| 1392604 | AA997187 | AA893032 | Nsdhl | NAD(P)-dependent steroid dehydrogenase-like | Down | Down |
| 1389906, 1367839 | AW530769 | H33426, M95591 | Fdft1 | Farnesyl diphosphate farnesyl transferase 1 | Down | Down |
| 1367668 | NM_031841 | AA875269 | SCD | Stearoyl-coenzyme A desaturase 2, δ-9-desaturase | Down | Down |
| 1387058 | NM_017225 | AF040261 | Pctp | Phosphatidylcholine transfer protein | Down | Down |
| 1388348, 1387630 | NM_134382 | AA892832 | ELO1 | ELOVL family member 5, elongation of long chain fatty acids | Down | Down |
| 1368075 | NM_012732 | AA874784, S81497 (2) | Lipa | Lysosomal acid lipase 1 | Down | Down |
| 1370024 | NM_030832 | U02096 | Fabp7 | Fatty acid binding protein 7 | Down | Down |
| 1370583, 1370465, 1370364, 1369161 | NM_012690 | L15079 | Abcb4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | Down | Down |
| 1398310 | D17309 | S80431, D17309 | Akr1d1 | Aldo-keto reductase family 1, member D1 | Down/up | Down |
| 1386965 | NM_012598 | AI237731, L03294 | Lpl | Lipoprotein lipase | Up | Down |
Probe sets regulated by MPL in rat liver after both acute and chronic drug administration and categorized as relating to lipid metabolism. Affymetrix 230A arrays use a probe set number distinct from GenBank accession numbers, whereas U34A chips use a common probe set/GenBank accession number for identification.