. 2014 Oct 15;76(8):664–671. doi: 10.1016/j.biopsych.2014.02.013

Table 2.

Associations of Polygenic Score with ADHD and ASD-Related Phenotypes in ALSPAC

Outcome	n	ZINB Count Outcome			ZINB Zero-Inflated Outcome			ZINB Overall p	ZINB Overall R²	Linear Regression^a
Outcome	n	β	SE	p	β	SE	p	ZINB Overall p	ZINB Overall R²	β	SE	p	R²
ADHD Total Traits	5661	.11	.10	.30	−.06	.02	.005	.0026^b	.005^b	.032	.013	.013	.001
ADHD Hyperactive-Impulsive Traits	5661	.15	.13	.24	−.05	.02	.024	.0039^b	.002^b	.037	.013	.005	.001
ADHD Inattentive Traits	5656	.05	.13	.71	−.05	.02	.019	.037^b	.002^b	.023	.013	.084	.001
SCDC Total Score	5653	.15	.19	.45	.02	.04	.67	.43^b	<.001^b	.012	.013	.35	.0002
CCC Pragmatic Language Score	5641									−.028	.013	.037^b	.001^b

All analyses used gender as a covariate. Polygenic scores derived using a threshold of p < .5 in the discovery sample genome-wide association study results (see text).

ADHD, attention-deficit/hyperactivity disorder; ALSPAC, Avon Longitudinal Study of Parents and Children; CCC, Children’s Communication Checklist; SCDC, Social and Communication Disorders Checklist; ZINB: zero-inflated negative binomial.

Linear regression results of ADHD and SCDC phenotypes included only for ease of interpretation.

Main result.