Table 4.

Replication Analyses—Associations of Polygenic Score Based on Second Discovery Sample with ADHD at Both Time Points

Time	Outcome	n	ZINB Count Outcome			ZINB Zero-Inflated Outcome			ZINB Overall p	ZINB Overall R2	Linear Regressiona
			β	SE	p	β	SE	p			β	SE	p	R2
Age 7	ADHD Total Traits	5661	.11	.11	.30	−.02	.02	.338	.20b	.001b	.023	.13	.052	.001
	ADHD Hyperactive-Impulsive Traits	5661	.05	.10	.58	−.03	.02	.20	.26b	<.001b	.020	.013	.12	.0004
	ADHD Inattentive Traits	5656	.18	.20	.39	−.02	.02	.44	.17b	<.001b	.027	.013	.043	.001
Age 10	ADHD Total Traits	5500	.27	.24	.26	−.02	.02	.45	.019b	<.001b	.26	.087	.003	.002
	ADHD Hyperactive-Impulsive Traits	5505	.30	.39	.44	−.01	.02	.56	.018b	<.001b	.13	.043	.003	.002
	ADHD Inattentive Traits	5495	.29	.33	.38	−.01	.02	.65	.055b	<.001b	.13	.052	.015	.001

All analyses used gender as a covariate. Polygenic scores derived using a threshold of p < .5 in the discovery sample genome-wide association study results (see text).

ADHD, attention-deficit/hyperactivity disorder; ZINB, zero-inflated negative binomial.

^aLinear regression results included only for ease of interpretation.

^bMain result.