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. 2014 Oct 2;8(10):e3212. doi: 10.1371/journal.pntd.0003212

Figure 4. Schematic view of the AQP2/3 variants identified in this study (adapted from Graf et al [20]).

Figure 4

Sequence of AQP3 was not verified. Positions of primer: black box = AQP2/3_F, green box = AQP2_R, red box = AQP2/3_R. A) Reference locus of AQP2 and AQP3, with wild-type AQP2 found in the melarsoprol and pentamidine sensitive strain T.b. gambiense LiTat 1.3 and in all strains from Masi-Manimba. B) Chimera of AQP2 and AQP3 occurring in a melarsoprol and pentamidine resistant T.b. brucei strain as described by Baker et al. [19]. C) Chimera of AQP2 and AQP3 plus loss of AQP3 in all T.b. gambiense strains from Mbuji-Mayi as described in this article and by Graf et al. [20]. D) New chimera of AQP2 and AQP3, possibly outside the known locus, found in all T.b. gambiense strains from Mbuji-Mayi. E) New chimera of AQP2 and AQP3 plus loss of AQP3 found in two old Congolese T.b. gambiense strains, MBA and KEMLO. F) New chimera of AQP2 and AQP3, without loss of AQP3, found in all four T.b. gambiense strains isolated in Masi-Manimba.