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. 2014 Oct 2;9(10):e108276. doi: 10.1371/journal.pone.0108276

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© 2014 Wilson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Inhibition of the JAK2/STAT3 pathway improves auditory brainstem response (ABR) threshold recovery from exposure to 4–48 kHz loud sound at 110 dB SPL for 3 hours. Mice were treated with JSI-124 (Cucurbitacin I) (1 mg/kg) or DMSO (Control) at 48 hours, 24 hours and 1 hour prior to sound exposure (n = 6 mice/group). ABR measurements were performed before (Baseline: normal hearing threshold), at 1 hour post (TTS: temporary threshold shift) and at 2 weeks post (PTS: permanent threshold shift) noise exposure. Significant protection was observed at 16 and 24 kHz. Data are presented as mean±SEM. *P<0.05.