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. 2014 Oct 2;8(10):e3198. doi: 10.1371/journal.pntd.0003198

Figure 4. Endogenous IFNγ limit parasite replication.

Figure 4

a) Parasite load in ex-vivo SA culture of VL patients (n = 31) treated with neutralizing anti-human-IFNγ antibodies or isotype control IgG2b antibodies for three days. Parasite load was determined by limiting dilution on NNN-blood agar medium. b) IL-10 levels in SA culture supernatants (n = 10), treated as described in a. c) Effect of CD4 depletion on spontaneous IFNγ production in SA-biopsy cultures. Each dot represents one sample, paired samples connected by a line. Comparison between treatments was made using Wilcoxon matched paired test and statistical significances are indicated in the graphs when P<0.05.