Figure 5. Treatment with RuBzNO₂ ameliorates heart inflammation and lesions induced by T. cruzi infection.

Mice were infected with 2000 trypomastigotes of T. cruzi and treated from day 5 for 10 days with various concentrations of Bz or RuBzNO₂. Twenty days after infection, the heart histology (A–B) was evaluated, and the CK-MB level (C) was measured in the serum. A. Representative photomicrograph of heart stained with H&E. B. Quantification of the inflammatory cells shown in A. The bars indicate means+SEM of 4–6 mice/experiment and are representative of two independent experiments. * represents p<0.05.