Table 2. Comparison of biomarkers and biomarker ratios in T. cruzi-infected (Tc+) vs uninfected (Tc−) subjects by stage.
| Tc+ Stage A | Tc− Stage A | Tc+ Stage B | Tc− Stage B | Tc+ Stage CD | Tc− Stage CD | |
| N = 66 | N = 48 | N = 41 | N = 9 | N = 86 | N = 15 | |
| Biomarker (pg/ml) | ||||||
| BNP | ||||||
| Median (IQR) | 74 (5–143) | 60 (5–147) | 60 (5–161) | 85 (65–260) | 150 (43–333) | 126 (19–193) |
| NTproBNP | ||||||
| Median (IQR) | 181 (121–321) | 135 (87–233) | 175 (124–296) | 218 (153–621) | 489 (263–981) | 337 (279–567) |
| CKMB | ||||||
| Median (IQR) | 3957(2697–5911) | 3532(2518–5639) | 4158 (2974–5748) | 4681(3174–4865) | 4693(3011–7615) | 5845 (4308–12549) |
| Troponin I | ||||||
| Median (IQR) | 42 (42–368) | 42 (42–296) | 151 (42–413) | 105 (42–871) | 240 (42–856) | 399 (78–2195) |
| MMP-2 | ||||||
| Median (IQR) | 79842 (68560–96981) | 81116 (74563–92850) | 81829 (70670–105747)’ | 101842 (83946–111654) | 98821 (75549–139488) | 90999 (78964–136924) |
| MMP-9 | ||||||
| Median (IQR) | 195508 (152132–303014) | 188300 (150727–239969) | 176644 (131517–251436) | 234599 (143093–330267) | 166872 (113575–303348) | 168461 (114684–319778) |
| TIMP-1 | ||||||
| Median (IQR) | 147458 (123524–188501) | 148468 (119882–200281) | 145538 (122239–184633) | 149220 (131043–205615) | 182433 (131095–231587) | 146117 (126184–227818) |
| TIMP-2 | ||||||
| Median (IQR) | 78493 (71547–96908) | 88002 (76403–131667) | 78770 (70988–92332) | 104752 (87134–113247) | 98220 (71187–117996) | 90351 (71597–99751) |
| TGFB1 | ||||||
| Median (IQR) | 30336 (24817–35773) | 32325 (26440–41304) | 28812 (22058–32456) | 30061 (28318–30968) | 26861 (20592–34694) | 25414 (24143–33194) |
| TGFB2 | ||||||
| Median (IQR) | 1163 (529–1840) | 1641 (992–2147) | 1177 (440–1861) | 1519(1096–1752) | 1100 (605–1701) | 883 (575–1518) |
| Biomarker Ratios | ||||||
| MMP-2/MMP-9 | ||||||
| Median (IQR) | 0.39 (0.28–0.54) | 0.44 (0.30–0.65) | 0.49 (0.35–0.72) | 0.48 (0.38–0.59) | 0.62 (0.30–1.16) | 0.83 (0.43–1.05) |
| MMP-2/TGFB1 | ||||||
| Median (IQR) | 2.7 (1.9–3.9) | 2.6 (2.0–3.3) | 3.0 (2.2–4.8) | 3.3 (2.8–3.9) | 4.1 (2.7–5.7) | 3.1 (2.4–3.6) |
| MMP-2/TIMP-2 | ||||||
| Median (IQR) | 1.04 (0.81–1.22) | 0.93 (0.73–1.08) | 1.08 (0.91–1.27) | 0.92 (0.78–1.21) | 1.11 (0.88–1.41) | 1.04 (0.98–1.12) |
| MMP-9/TIMP-1 | ||||||
| Median (IQR) | 1.41 (1.02–2.37) | 1.27 (0.83–1.73) | 1.22 (0.78–1.81) | 1.37 (0.60–1.79) | 0.93 (0.58–1.82) | 1.04 (0.63–2.31) |
Bolded values represent a significant difference between Tc+ or Tc− individuals at a p<0.05.