Table 4.
Associations between BMI change and UADT SCCs, stratified by UADT risk factors.
| Variable | BMI change from age 30 to 2 years prior to study entry | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Loss (<-5%) | Stable (−5% to < +5%) | Gain (≥ +5%) | Ptrend | |||
| Smoking Status | ||||||
| Never smoker | ||||||
| cases/controls | 23/71 | 36/171 | 102/430 | |||
| OR (95% CI) 1 | 1.23 | (0.65, 2.33) | 1.00 | 0.95 | (0.60, 1.50) | 0.398 |
| Former smoker | ||||||
| cases/controls | 52/67 | 93/161 | 247/431 | |||
| OR (95% CI) 1 | 1.19 | (0.73, 1.94) | 1.00 | 0.93 | (0.67, 1.29) | 0.284 |
| Current smoker | ||||||
| cases/controls | 205/64 | 437/169 | 439/293 | |||
| OR (95% CI) 1 | 1.08 | (0.75, 1.54) | 1.00 | 0.59 | (0.46, 0.76) | <0.001 |
| Drinking Status | ||||||
| Never drinker | ||||||
| cases/controls | 14/41 | 24/54 | 53/134 | |||
| OR (95% CI) 1 | 0.57 | (0.23, 1.41) | 1.00 | 0.85 | (0.43, 1.69) | 0.474 |
| Former drinker | ||||||
| cases/controls | 55/32 | 89/39 | 110/106 | |||
| OR (95% CI) 1 | 0.83 | (0.42, 1.65) | 1.00 | 0.44 | (0.25, 0.78) | 0.015 |
| Current drinker | ||||||
| cases/controls | 211/129 | 453/408 | 624/914 | |||
| OR (95% CI) 1 | 1.28 | (0.95, 1.74) | 1.00 | 0.79 | (0.64, 0.96) | <0.001 |
| Smoking and Drinking status | ||||||
| Never smoker/drinker | ||||||
| cases/controls | 6/23 | 9/36 | 23/90 | |||
| OR (95% CI) 1 | 0.86 | (0.22, 3.29) | 1.00 | 0.99 | (0.35, 2.86) | 0.844 |
| Drinker but not a smoker | ||||||
| cases/controls | 8/18 | 15/18 | 31/44 | |||
| OR (95% CI) 1 | 0.30 | (0.07, 1.21) | 1.00 | 0.73 | (0.25, 2.13) | 0.277 |
| Smoker but not a drinker | ||||||
| cases/controls | 17/48 | 27/135 | 79/340 | |||
| OR (95% CI) 1 | 1.28 | (0.60, 2.76) | 1.00 | 0.95 | (0.56, 1.62) | 0.429 |
| Smoker and drinker | ||||||
| cases/controls | 249/113 | 515/312 | 655/680 | |||
| OR (95% CI) 1 | 1.19 | (0.89, 1.59) | 1.00 | 0.63 | (0.52, 0.77) | <0.001 |
| Fruit and Vegetable intake2 | ||||||
| Low fruits and vegetables | ||||||
| cases/controls | 171/70 | 369/203 | 442/477 | |||
| OR (95% CI) 1 | 1.26 | (0.86, 1.83) | 1.00 | 0.63 | (0.49, 0.81) | <0.001 |
| Medium fruit and vegetables | ||||||
| cases/controls | 67/90 | 138/178 | 240/426 | |||
| OR (95% CI) 1 | 0.76 | (0.48, 1.20) | 1.00 | 0.85 | (0.61, 1.17) | 0.956 |
| High fruit and vegetables | ||||||
| cases/controls | 42/42 | 59/120 | 106/251 | |||
| OR (95% CI) 1 | 2.06 | (1.10, 3.86) | 1.00 | 1.03 | (0.64, 1.64) | 0.047 |
| BMI at age 30 (kg/m2) | ||||||
| <18.5 | ||||||
| cases/controls | 2/0 | 16/7 | 41/50 | |||
| OR (95% CI) 1 | -- | 1.00 | 0.18 | (0.02, 1.46) | 0.081 | |
| 18.5 to <25 | ||||||
| cases/controls | 120/62 | 401/314 | 538/810 | |||
| OR (95% CI) 1 | 1.50 | (1.00, 2.24) | 1.00 | 0.72 | (0.57, 0.90) | <0.001 |
| 25 to <30 | ||||||
| cases/controls | 98/74 | 123/136 | 179/256 | |||
| OR (95% CI) 1 | 1.15 | (0.71, 1.84) | 1.00 | 0.71 | (0.48, 1.03) | 0.018 |
| ≥ 30 | ||||||
| cases/controls | 60/66 | 26/42 | 29/38 | |||
| OR (95% CI) 1 | 1.34 | (0.62, 2.91) | 1.00 | 1.41 | (0.59, 3.34) | 0.997 |
| Time between age 30 and interview 3 | ||||||
| Quartile 1 | ||||||
| cases/controls | 49/41 | 165/129 | 126/210 | |||
| OR (95% CI) 1 | 0.77 | (0.43, 1.37) | 1.00 | 0.49 | (0.33, 0.73) | 0.009 |
| Quartile 2 | ||||||
| cases/controls | 89/42 | 176/139 | 237/327 | |||
| OR (95% CI) 1 | 1.68 | (1.00, 2.81) | 1.00 | 0.78 | (0.56, 1.09) | 0.002 |
| Quartile 3 | ||||||
| cases/controls | 68/41 | 126/114 | 222/313 | |||
| OR (95% CI) 1 | 1.27 | (0.72, 2.25) | 1.00 | 0.79 | (0.54, 1.15) | 0.047 |
| Quartile 4 | ||||||
| cases/controls | 74/78 | 99/117 | 203/304 | |||
| OR (95% CI) 1 | 1.06 | (0.65, 1.72) | 1.00 | 0.90 | (0.62, 1.31) | 0.428 |
Paris center not included in the model. Adjusted for center, education, sex, age, fruit and vegetable intake, tobacco status/frequency, and alcohol frequency, when appropriate.
Fruit and vegetable categories based on center-specific fruit and center-specific vegetable tertile distributions. Low: at least one intake group in the lowest tertile and the other intake group in the mid tertile; Mid: both groups in the mid-center-specific tertile or one of the fruit and vegetable group at either extreme tertile (i.e. lowest tertile in fruit, highest tertile in vegetable); High: both intakes in the highest tertile or one in the high and one in the middle tertile.
Quartile 1: <22 years, quartile 2: 22≤time to disease <30, quartile 3: 30≤ time to disease<38, and quartile 4: ≥38 years.