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. 2014 Oct 2;9(10):e108999. doi: 10.1371/journal.pone.0108999

Table 2. Measurement of ventricular dimensions in WT and GPR55−/− mice.

Young Mice (10 week old) Mature Mice (8 month old)
WT (n = 15) GPR55−/− (n = 15) WT (n = 14) GPR55−/− (n = 14)
HW∶BW (mg/g) 3.07±0.06 3.19±0.1 3.98±0.06* 3.59±0.02
LV Wall Thickness (mm) 1.68±0.04 1.79±0.11 1.92±0.05* 1.65±0.07
RV Wall Thickness (mm) 0.39±0.02 0.38±0.04 0.36±0.04 0.40±0.01
Interventricular Septal Thickness (mm) 1.25±0.04 1.22±0.06 1.31±0.01 1.35±0.02
Chamber Area (% of LV) 13.9±0.9 15.5±1.3 12.8±0.7 13.2±0.8
Cardiomyocyte CSA (µm2) 89±9 94±8 145±5* 144±7
Nuclei number (nuclei/mm2) 6726±284 6456±169 6471±393 4983±405#

Ventricular dimensions did not differ significantly between young WT and GPR55−/− mice, however mature GPR55−/− mice were characterised by significant myocardial remodelling; including a reduction in left ventricular (LV) free wall thickness, myocardial nuclei number, and HW∶BW, and increased collagen deposition. Data is expressed as mean±s.e.m. (n = 14–15).

*P<0.05 vs. WT (Young);

#

P<0.05 vs. GPR55−/− (Young);

P<0.05 vs. WT (Mature).