Figure 1. Microarray analysis identified Adseverin as a gene of interest during the early phases of OCG.

Several genes were differentially expressed in osteoclast precursors stimulated for two days with sRANKL & M-CSF versus M-CSF alone. Eight cytoskeleton-associated genes with the greatest fold-change in expression (p<0.05) were reported. Specifically, Ads was up-regulated 4.9-fold in osteoclast precursors stimulated with sRANKL for two days. The microarray data has been deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GSE54779.