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NaAsO2 inhibits histone H2B K120 ubiquitination in cells. (a) The product-ion spectrum (MS/MS) of the [M + 2H]2+ ion of the tryptic peptide AVTKGGVTSSK from histone H2B, where K120 is modified with a diglycine remnant. An asterisk (*) indicates those ions bearing a diglycine moiety. (b) Relative levels of H2B ubiquitination in GM00637, IMR90, and HEK293T cells without or with a 24 h treatment of 5 μM NaAsO2.
