Table 4. Efficiency and Enantioselectivity of 1, 5, 6b–6i, and ent-7 in ARCM of 13.
entry | catalyst | conversion (%)a | ee (%)b |
---|---|---|---|
1 | ent-7 | <2 | ND |
2 | 6b | >98 | 42 |
3 | 6c | 35 | 36 |
4 | 6d | 35 | 53 |
5 | 6e | 76 | 46 |
6 | 6f | >98 | 18 |
7 | 6g | >98 | 42 |
8 | 6h | 48 | 43 |
9 | 6i | 72 | 40 |
10 | 5 | >98 | 54 |
11 | 1 | 20 | 0 |
Determined by 1H NMR spectroscopy;
Determined by chiral SFC analysis