Table 1. GLP-1R Activation, Monitored by cAMP Production for GLP-1(7-36)-NH2 and Analogues.
EC50 (nM) | max response (% GLP-1 max) | |
---|---|---|
GLP-1 | 1.6 ± 0.2 | 100 |
1 | >100 | – |
2 | 0.7 ± 0.1 | 100 |
3 | 2.0 ± 0.1 | 85 |
4 | 4.0 ± 0.5 | 103 |
5 | >100 | – |
6 | 3.2 ± 0.3 | 88 |