Table 4. Important small-molecule targets of LC-O3PUFAs in spinal cord injured rats.
Fold changes when compared to injured rats receiving control diets. The additional columns illustrate the individual effects of diet and SCI in the regulating the levels of each biochemical. Up arrow, upregulation; down arrow, downregulation; =, not significant change.
| One Week Post-SCI (LC-O3PUFA Diet/Control Diet) | |||
|---|---|---|---|
| Metabolite | Fold-chage | Diet Effect | SCI Effect |
| N-acetylglutamate | 1.43 |
|
|
| cystathionine | 1.43 |
|
= |
| Methionine and acetylmethionine | 0.91, 0.88 |
|
|
| arginine | 0.90 |
|
|
| ornithine | 1.76 |
|
|
| urea | 1.36 |
|
= |
| maltose and maltotriose | 1.62, 2.18 |
|
|
| hypoxanthine | 0.90 |
|
= |
| heme | 2.92 |
|
= |
| phosphopantetheine | 0.84 |
|
|
| hippurate | 2.19 |
|
= |
| Eight Weeks Post-SCI (LC-O3PUFA Diet/Control Diet) | |||
|---|---|---|---|
| Metabolite | Fold-chage | Diet Effect | SCI Effect |
| asparagine | 0.75 |
|
= |
| N2-acetyllysine | 1.49 |
|
= |
| 2-aminobutyrate | 0.54 |
|
= |
| 5-methylthioadenosine (MTA) | 1.19 |
|
= |
| 4-guanidinobutanoate | 1.27 |
|
= |
| glutathione, reduced (GSH) | 1.42 |
|
= |
| glutathione, oxidized (GSSG) | 1.34 |
|
|
| anserine | 0.50 |
|
= |
| gamma-glutamylglutamine | 1.15 |
|
|
| maltose | 1.71 |
|
|
| maltriose | 1.17 |
|
= |
| citrate | 1.30 |
|
|
| cytidine | 1.20 |
|
|
| uridine | 1.15 |
|
= |
| methylphosphate | 1.26 |
|
= |
| ergothioneine | 0.52 |
|
= |