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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mol Neurobiol. 2014 Apr 17;50(1):197–213. doi: 10.1007/s12035-014-8701-1

Table 5. Complete non-lipid metabolomic profile at one-week post-operation.

Data represents averages of scaled metabolite amount ± standard deviation. For each detected metabolite, the raw area counts were re-scaled to set the median metabolite relative amount equal to 1. The Human Metabolome Database (HMDB) identifier has been provided. The green color in the heat map indicates averaged median values equal or lower than 1.5-fold from the median metabolite amount of 1, whereas red indicates averaged median values equal or higher than 1.5-fold from the median metabolite amount.

Metabolite
1 week		 HMDB Subpathway Control: SCI Control: Sham O3PUFA: SCI O3PUFA: Sham
Average
Median Metabolite Levels		 Standard
Deviation		 Average
Median Metabolite Levels		 Standard
Deviation		 Average
Median Metabolite Levels		 Standard
Deviation		 Average
Median Metabolite Levels		 Standard
Deviation
Amino Acids 2-aminoadipate HMDB00510 Lysine Metabolism 1.18 0.28 1.07 0.25 1.07 0.25 0.65 0.27
2-aminobutyrate HMDB00650 Butanoate metabolism 1.66 0.90 0.79 0.29 0.79 0.29 0.69 0.35
2-methylbutyroylcarnitine (C5) HMDB00378 Valine, leucine and isoleucine metabolism 1.14 0.36 0.38 0.03 0.38 0.03 0.38 0.04
3-(4-hydroxyphenyl)lactate (HPLA) HMDB00755 Phenylalanine & tyrosine metabolism 1.41 0.36 0.74 0.21 0.74 0.21 0.75 0.08
3-hydroxyisobutyrate HMDB00336 Valine, leucine and isoleucine metabolism 1.04 0.26 0.84 0.36 0.84 0.36 0.79 0.29
3-phosphoserine HMDB00272 Glycine, serine and threonine metabolism 0.94 0.37 1.01 0.33 1.01 0.33 1.01 0.28
4-guanidinobutanoate HMDB03464 Guanidino and acetamido metabolism 1.22 0.18 0.80 0.26 0.80 0.26 0.82 0.20
5-aminovalerate HMDB03355 Urea cycle; arginine-, proline-, metabolism 1.12 0.12 0.80 0.15 0.80 0.15 0.79 0.16
5-methylthioadenosine (MTA) HMDB01173 Polyamine metabolism 0.88 0.16 1.08 0.17 1.08 0.17 1.11 0.14
5-oxoproline HMDB00267 Glutathione metabolism 0.93 0.07 1.08 0.09 1.08 0.09 1.09 0.13
alanine HMDB00161 Alanine and aspartate metabolism 1.17 0.16 0.78 0.10 0.78 0.10 0.82 0.10
arginine HMDB00517 Urea cycle; arginine-, proline-, metabolism 1.08 0.10 0.97 0.08 0.97 0.08 0.96 0.07
asparagine HMDB00168 Alanine and aspartate metabolism 1.34 0.21 0.77 0.19 0.77 0.19 0.77 0.12
aspartate HMDB00191 Alanine and aspartate metabolism 0.81 0.06 1.26 0.17 1.26 0.17 1.39 0.13
beta-alanine HMDB00056 Alanine and aspartate metabolism 0.92 0.10 0.90 0.23 0.90 0.23 1.12 0.24
betaine HMDB0043 Glycine, serine and threonine metebolism 1.42 0.11 0.65 0.15 0.65 0.15 0.70 0.11
C-glycosyltryptophan* Tryptophan metabolism 1.41 0.59 0.93 0.23 0.93 0.23 0.94 0.18
citrulline HMDB00904 Urea cycle; arginine-, proline-, metabolism 1.64 0.35 0.61 0.15 0.61 0.15 0.53 0.10
creatine HMDB00064 Creatine metabolism 0.88 0.12 1.05 0.17 1.05 0.17 1.06 0.21
creatinine HMDB00562 Creatine metabolism 0.95 0.18 1.10 0.22 1.10 0.22 1.14 0.19
cystathionine HMDB00099 Cysteine, methionine, SAM, taurine metabolism 0.94 0.26 1.06 0.24 1.06 0.24 1.01 0.17
cysteine HMDB00574 Cysteine, methionine, SAM, taurine metabolism 1.04 0.15 0.90 0.15 0.90 0.15 0.95 0.09
cysteine-glutathione disulfide HMDB00656 Glutathione metabolism 1.49 0.43 0.81 0.12 0.81 0.12 0.79 0.23
cystine HMDB00192 Cysteine, methionine, SAM, taurine metabolism 0.99 0.35 0.99 0.32 0.99 0.32 0.72 0.15
gamma-aminobutyrate (GABA) HMDB00112 Glutamate metabolism 0.72 0.09 1.29 0.15 1.29 0.15 1.40 0.23
glutamate HMDB03339 Glutamate metabolism 0.86 0.07 1.10 0.07 1.10 0.07 1.14 0.11
glutamine HMDB00641 Glutamate metabolism 0.96 0.11 1.05 0.11 1.05 0.11 0.90 0.14
glutathione, oxidized (GSSG) HMDB03337 Glutathione metabolism 1.80 1.87 0.95 0.27 0.95 0.27 0.97 0.35
glutathione, reduced (GSH) HMDB00125 Glutathione metabolism 1.06 0.34 1.07 0.26 1.07 0.26 1.15 0.23
glycine HMDB00123 Glycine, serine and threonine metabolism 0.95 0.12 1.08 0.14 1.08 0.14 1.15 0.13
histidine HMDB00177 Histidine metabolism 1.45 0.26 0.72 0.08 0.72 0.08 0.75 0.09
hydroxyisovaleroylcarnitine (C5) Valine, leucine and isoleucine metabolism 1.68 0.32 0.67 0.14 0.67 0.14 0.67 0.16
hypotaurine HMDB00965 Cysteine, methionine, SAM, taurine metabolism 1.74 0.28 0.54 0.14 0.54 0.14 0.62 0.11
isoleucine HMDB00172 Valine, leucine and isoleucine metabolism 1.43 0.15 0.82 0.07 0.82 0.07 0.82 0.07
isovalerylcarnitine (C5) HMDB00688 Valine, leucine and isoleucine metabolism 1.41 0.55 0.23 0.11 0.23 0.11 0.19 0.10
kynurenine HMDB00684 Tryptophan metabolism 2.15 3.86 2.58 5.01 2.58 5.01 4.84 4.10
leucine HMDB00687 Valine, leucine and isoleucine metabolism 1.43 0.10 0.79 0.05 0.79 0.05 0.80 0.07
lysine HMDB00182 Lysine metabolism 1.22 0.31 0.89 0.11 0.89 0.11 0.93 0.05
methionine HMDB00696 Cysteine, methionine, SAM, taurine metabolism 1.28 0.11 0.86 0.06 0.86 0.06 0.88 0.06
N-acetyl-aspartyl-glutamate (NAAG) HMDB01067 Glutamate metabolism 0.71 0.05 1.18 0.06 1.18 0.06 1.14 0.05
N-acetylalanine HMDB00766 Alanine and aspartate metabolism 1.25 0.15 0.88 0.10 0.88 0.10 0.95 0.05
N-acetylaspartate (NAA) HMDB00812 Alanine and aspartate metabolism 0.49 0.16 1.46 0.16 1.46 0.16 1.31 0.23
N-acetylglutamate HMDB01138 Glutamate metabolism 0.61 0.20 1.23 0.35 1.23 0.35 1.34 0.28
N-acetylmethionine HMDB11745 Cysteine, methionine, SAM, taurine metabolism 1.58 0.16 0.62 0.04 0.62 0.04 0.67 0.09
N-acetylthreonine Glycine, serine and threonine metabolism 1.27 0.29 0.78 0.10 0.78 0.10 0.77 0.11
N2-acetyllysine HMDB00446 Lysine metabolism 1.04 0.28 1.18 0.22 1.18 0.22 1.08 0.24
N6-acetyllysine HMDB00206 Lysine metabolism 1.12 0.18 0.91 0.24 0.91 0.24 0.93 0.13
ornithine HMDB03374 Urea cycle; arginine-, proline-, metabolism 1.82 0.65 0.84 0.11 0.84 0.11 0.85 0.08
phenylalanine HMDB00159 Phenylalanine & tyrosine metabolism 1.44 0.15 0.83 0.09 0.83 0.09 0.83 0.08
pipecolate HMDB00070 Lysine metabolism 0.99 0.29 0.72 0.36 0.72 0.36 0.66 0.28
proline HMDB00162 Urea cycle; arginine-, proline-, metabolism 1.27 0.12 0.88 0.08 0.88 0.08 0.83 0.06
putrescine HMDB01414 Polyamine metabolism 1.42 0.24 0.42 0.05 0.42 0.05 0.52 0.17
S-adenosylhomocysteine (SAH) HMDB00939 Cysteine, methionine, SAM, taurine metabolism 0.84 0.12 1.14 0.12 1.14 0.12 1.10 0.10
sarcosine (N-Methylglycine) HMDB00271 Glycine, serine and threonine metabolism 0.97 0.13 1.06 0.15 1.06 0.15 1.01 0.23
serine HMDB00187 Glycine, serine and threonine metabolism 1.21 0.19 0.77 0.13 0.77 0.13 0.80 0.10
spermidine HMDB01257 Polyamine metabolism 1.18 0.74 0.95 0.11 0.95 0.11 1.14 0.30
taurine HMDB00251 Cysteine, methionine, SAM, taurine metabolism 1.70 0.51 0.72 0.22 0.72 0.22 0.78 0.18
threonine HMDB00167 Glycine, serine and threonine metabolism 1.11 0.13 0.98 0.21 0.98 0.21 0.71 0.16
hydroxyproline HMDB00725 Urea cycle; arginine-, proline-, metabolism 1.48 0.67 0.64 0.23 0.64 0.23 0.48 0.15
tryptophan HMDB00929 Tryptophan metabolism 1.23 0.10 0.82 0.11 0.82 0.11 0.83 0.13
tyrosine HMDB00158 Phenylalanine & tyrosine metabolism 1.37 0.13 0.75 0.08 0.75 0.08 0.77 0.07
urea HMDB00294 Urea cycle; arginine-, proline-, metabolism 0.85 0.28 0.75 0.21 0.75 0.21 1.07 0.26
valine HMDB00883 Valine, leucine and isoleucine metabolism 1.42 0.11 0.84 0.06 0.84 0.06 0.85 0.06
Carbohydrates dihydroxyacetone HMDB01882 Glycolysis, gluconeogenesis, pyruvate metabolism 1.18 0.41 0.84 0.51 0.84 0.51 1.22 0.59
1, 5-anhydroglucitol (1, 5-AG) HMDB02712 Glycolysis, gluconeogenesis, pyruvate metabolism 1.24 0.23 0.74 0.22 0.74 0.22 0.81 0.29
3-phosphoglycerate HMDB00807 Glycolysis, gluconeogenesis, pyruvate metabolism 0.99 0.20 1.03 0.14 1.03 0.14 0.93 0.16
arabinose HMDB00646 Nucleotide sugars, pentose metabolism 0.98 0.15 0.98 0.14 0.98 0.14 1.08 0.18
arabitol HMDB01851 Nucleotide sugars, pentose metabolism 1.05 0.52 1.21 0.36 1.21 0.36 0.99 0.29
dihydroxyacetone phosphate (DHAP) HMDB01473 Glycolysis, gluconeogenesis, pyruvate metabolism 0.92 0.22 0.94 0.19 0.94 0.19 1.00 0.22
erythronate* HMDB00613 Aminosugars metabolism 1.26 0.29 1.02 0.14 1.02 0.14 0.80 0.11
fructose HMDB00660 Fructose, mannose, galactose, starch, and sucrose metabolism 1.24 0.40 0.79 0.13 0.79 0.13 0.91 0.34
fructose 6-phosphate HMDB00124 Glycolysis, gluconeogenesis, pyruvate metabolism 1.62 0.47 0.80 0.10 0.80 0.10 0.82 0.26
glucose HMDB00122 Glycolysis, gluconeogenesis, pyruvate metabolism 2.26 1.26 0.22 0.06 0.22 0.06 0.38 0.36
glucose 6-phosphate HMDB01401 Glycolysis, gluconeogenesis, pyruvate metabolism 1.54 0.47 0.68 0.10 0.68 0.10 0.72 0.24
glycerate HMDB00139 Glycolysis, gluconeogenesis, pyruvate metabolism 1.28 0.31 0.95 0.32 0.95 0.32 0.93 0.20
Isobar: hexose diphosphates Glycolysis, gluconeogenesis, pyruvate metabolism 1.00 0.39 0.86 0.26 0.86 0.26 1.00 0.32
Isobar: ribulose 5-phosphate, xylulose 5-phosphate Nucleotide sugars, pentose metabolism 1.05 0.24 0.94 0.09 0.94 0.09 0.96 0.18
lactate HMDB00190 Glycolysis, gluconeogenesis, pyruvate metabolism 1.01 0.12 0.99 0.11 0.99 0.11 1.04 0.13
maltose HMDB00163 Fructose, mannose, galactose, starch, and sucrose metabolism 1.53 0.72 0.44 0.07 0.44 0.07 0.47 0.08
maltotriose HMDB01262 Fructose, mannose, galactose, starch, and sucrose metabolism 0.84 0.55 0.26 0.01 0.26 0.01 0.28 0.04
mannitol HMDB00765 Fructose, mannose, galactose, starch, and sucrose metabolism 0.84 0.50 0.62 0.22 0.62 0.22 0.80 0.38
mannose HMDB00169 Fructose, mannose, galactose, starch, and sucrose metabolism 1.65 0.45 0.57 0.14 0.57 0.14 0.61 0.16
mannose 6-phosphate HMDB01078 Fructose, mannose, galactose, starch, and sucrose metabolism 1.61 0.47 0.72 0.14 0.72 0.14 0.74 0.26
N-acetylneuraminate HMDB00230 Aminosugars metabolism 1.03 0.11 1.04 0.20 1.04 0.20 0.87 0.18
ribitol HMDB00508 Nucleotide sugars, pentose metabolism 1.02 0.37 1.05 0.33 1.05 0.33 0.96 0.24
ribose HMDB00283 Nucleotide sugars, pentose metabolism 0.99 0.17 1.16 0.31 1.16 0.31 1.45 0.60
ribulose HMDB00621 Nucleotide sugars, pentose metabolism 1.11 0.37 0.76 0.31 0.76 0.31 0.81 0.33
sedoheptulose-7-phosphate HMDB01068 Nucleotide sugars, pentose metabolism 1.37 0.55 1.61 0.36 0.61 0.36 0.94 0.41
sorbitol HMDB00247 Fructose, mannose, galactose, starch, and sucrose metabolism 1.13 0.40 0.86 0.25 0.86 0.25 0.93 0.27
sucrose HMDB00258 Fructose, mannose, galactose, starch, and sucrose metabolism 1.76 0.15 0.72 0.03 0.72 0.03 1.02 0.82
Cofactors and vitamins 3′-dephosphocoenzyme A HMDB01373 Pantothenate and CoA metabolism 0.79 0.34 1.20 0.41 1.20 0.41 1.52 0.66
alpha-tocopherol HMDB01893 Tocopherol metabolism 1.23 1.15 0.91 0.08 0.91 0.08 0.93 0.24
ascorbate (Vitamin C) HMDB00044 Ascorbate and aldarate metabolism 1.23 0.23 0.77 0.14 0.77 0.14 0.85 0.15
CoA HMDB01423 Pantothenate and CoA metabolism 0.76 0.32 1.58 0.77 1.58 0.77 1.74 0.87
dehydroascorbate HMDB01264 Ascorbate and aldarate metabolism 1.03 0.48 0.92 0.22 0.92 0.22 0.90 0.35
dihydrobiopterin HMDB00038 Tetrahydrobiopterin metabolism 1.11 0.28 0.71 0.15 0.71 0.15 0.62 0.00
FAD HMDB01248 Riboflavin metabolism 1.00 0.10 0.95 0.08 0.95 0.08 1.02 0.08
heme HMDB03178 Hemoglobin and porphyrin metabolism 0.71 0.12 0.68 0.05 0.68 0.05 0.80 0.27
nicotinamide HMDB01406 Nicotinate and nicotinamide metabolism 0.88 0.07 1.06 0.07 1.06 0.07 1.09 0.08
NAD+ HMDB00902 Nicotinate and nicotinamide metabolism 0.88 0.13 1.07 0.21 1.07 0.21 1.07 0.17
pantothenate (Vitamin B5) HMDB00210 Pantothenate and CoA metabolism 1.00 0.16 1.00 0.16 1.00 0.16 1.08 0.20
phosphopantetheine HMDB01416 Pantothenate and CoA metabolism 0.91 0.10 1.12 0.13 1.12 0.13 1.18 0.14
pyridoxal HMDB01545 Pyridoxal metabolism 1.02 0.17 0.97 0.31 0.97 0.31 1.08 0.29
riboflavin (Vitamin B2) HMDB00244 Riboflavin metabolism 1.11 0.12 0.84 0.12 0.84 0.12 0.92 0.16
Energy cis-aconitate HMDB00072 Krebs cycle 1.49 0.18 0.61 0.09 0.61 0.09 0.66 0.10
citrate HMDB00094 Krebs cycle 1.66 0.38 0.65 0.09 0.65 0.09 0.69 0.10
fumarate HMDB00134 Krebs cycle 1.01 0.22 1.04 0.17 1.04 0.17 1.15 0.23
malate HMDB00153 Krebs cycle 1.10 0.16 0.96 0.07 0.96 0.07 1.01 0.14
phosphate HMDB01429 Oxidative phosphorylation 0.97 0.04 1.02 0.03 1.02 0.03 1.07 0.05
pyrophosphate (PPi) HMDB00250 Oxidative phosphorylation 0.85 0.50 0.75 0.41 0.75 0.41 1.03 0.66
succinylcarnitine (C4) Krebs cycle 1.20 0.30 0.76 0.19 0.76 0.19 0.92 0.13
Nucleotides 2′-deoxycytidine HMDB00014 Pyrimidine metabolism, cytidine containing 1.45 0.20 0.64 0.09 0.64 0.09 0.67 0.13
2′-deoxyinosine HMDB00071 Purine metabolism, (hypo)xanthine/inosine containing 1.15 0.44 0.46 0.00 0.46 0.00 0.46 0.00
5,6-dihydrouracil HMDB00076 Purine metabolism, adenine containing 1.04 0.39 1.08 0.18 1.08 0.18 0.95 0.23
adenine HMDB00034 Purine metabolism, adenine containing 0.78 0.15 1.29 0.15 1.29 0.15 1.23 0.22
adenosine HMDB00050 Purine metabolism, adenine containing 0.33 0.16 1.56 0.43 1.56 0.43 1.75 0.39
2′-AMP HMDB11617 Purine metabolism, adenine containing 1.13 0.48 0.85 0.22 0.85 0.22 0.82 0.28
3′-AMP HMDB03540 Purine metabolism, adenine containing 1.18 0.14 0.76 0.16 0.76 0.16 0.75 0.18
AMP HMDB00045 Purine metabolism, urate metabolism 0.80 0.15 1.17 0.36 1.17 0.36 1.34 0.23
allantoin HMDB00462 Pyrimidine metabolism, cytidine containing 1.16 0.58 0.87 0.35 0.87 0.35 1.00 0.56
cytidine HMDB00089 Pyrimidine metabolism, cytidine containing 1.09 0.07 0.94 0.04 0.94 0.04 0.96 0.06
3′-CMP Purine metabolism, guanine containing 0.92 0.15 0.98 0.15 0.98 0.15 1.09 0.18
guanosine HMDB00133 Purine metabolism, (hypo)xanthine/inosine containing 0.54 0.09 1.33 0.10 1.33 0.10 1.25 0.18
hypoxanthine HMDB00157 Purine metabolism, (hypo)xanthine/inosine containing 1.02 0.07 1.00 0.09 1.00 0.09 1.02 0.10
inosine HMDB00195 Purine and pyrimidine metabolism 0.79 0.07 1.05 0.06 1.05 0.06 1.09 0.04
methylphosphate Purine metabolism, adenine containing 0.94 0.14 1.07 0.11 1.07 0.11 1.09 0.13
1-methyladenosine HMDB03331 Pyrimidine metabolism, uracil containing 1.21 0.31 0.86 0.18 0.86 0.18 0.90 0.35
pseudouridine HMDB00767 Pyrimidine metabolism, uracil containing 1.36 0.31 0.76 0.19 0.76 0.19 0.81 0.08
uracil HMDB00300 Purine metabolism, urate metabolism 1.30 0.17 0.76 0.14 0.76 0.14 0.78 0.12
urate HMDB00289 Pyrimidine metabolism, uracil containing 1.64 0.37 0.54 0.24 0.54 0.24 0.48 0.12
uridine HMDB00296 Purine metabolism, (hypo)xanthine/inosine containing 0.77 0.10 1.17 0.12 1.17 0.12 1.10 0.16
xanthine HMDB00292 Purine metabolism, (hypo)xanthine/inosine containing 1.12 0.16 0.94 0.09 0.94 0.09 0.94 0.09
xanthosine HMDB00299 Dipeptide derivative 1.28 0.25 0.78 0.14 0.78 0.14 0.72 0.15
Peptides anserine HMDB00194 Dipeptide derivative 0.70 0.31 1.61 1.53 1.61 1.53 2.15 1.47
carnosine HMDB00033 gamma-glutamyl 0.58 0.04 0.99 0.31 0.99 0.31 1.31 0.23
gamma-glutamylalanine gamma-glutamyl 1.37 0.23 0.80 0.15 0.80 0.15 0.80 0.22
gamma-glutamylglutamate gamma-glutamyl 0.85 0.11 1.15 0.15 1.15 0.15 1.19 0.19
gamma-glutamylglutamine HMDB11738 gamma-glutamyl 1.02 0.21 0.92 0.10 0.92 0.10 0.94 0.14
gamma-glutamylglycine HMDB11667 gamma-glutamyl 0.71 0.21 1.11 0.25 1.11 0.25 1.31 0.31
gamma-glutamylleucine HMDB11171 gamma-glutamyl 1.20 0.15 0.75 0.21 0.75 0.21 0.80 0.10
gamma-glutamylmethionine gamma-glutamyl 1.18 0.16 0.92 0.18 0.92 0.18 0.81 0.20
gamma-glutamylphenylalanine HMDB00594 gamma-glutamyl 1.11 0.23 0.89 0.16 0.89 0.16 0.89 0.16
gamma-glutamylthreonine* gamma-glutamyl 1.09 0.17 0.97 0.11 0.97 0.11 0.89 0.20
gamma-glutamyltyrosine Dipeptide 1.08 0.11 0.82 0.33 0.82 0.33 0.91 0.29
glycylglycine HMDB11733 Dipeptide 1.26 0.34 0.93 0.18 0.93 0.18 0.90 0.07
glycylleucine HMDB00759 Dipeptide 1.17 0.21 0.90 0.09 0.90 0.09 0.97 0.15
glycylphenylalanine Dipeptide derivative 1.08 0.11 0.79 0.22 0.79 0.22 0.77 0.23
homocarnosine HMDB00745 Dipeptide 0.82 0.17 1.07 0.13 1.07 0.13 1.36 0.17
isoleucylglycine Dipeptide 1.15 0.27 0.95 0.12 0.95 0.12 0.93 0.13
leucylglycine Dipeptide 1.00 0.29 1.08 0.28 1.08 0.28 1.25 0.37
leucylserine Dipeptide 1.56 0.24 0.76 0.19 0.76 0.19 0.62 0.22
phenylalanylglycine Dipeptide 1.23 0.42 0.28 0.06 0.28 0.06 0.28 0.05
phenylalanylphenylalanine Dipeptide 1.30 0.31 0.31 0.08 0.31 0.08 0.46 0.23
phenylalanylserine Dipeptide 2.04 0.57 0.82 0.16 0.82 0.16 0.90 0.08
prolylmethionine Dipeptide 1.35 0.34 0.85 0.14 0.85 0.14 0.86 0.19
threonylalanine Dipeptide 0.98 0.27 0.98 0.30 0.98 0.30 1.11 0.37
tryptophylglycine Dipeptide 1.37 0.33 0.91 0.13 0.91 0.13 0.81 0.21
tyrosylglycine Dipeptide 1.77 0.29 0.62 0.12 0.62 0.12 0.64 0.14
tyrosylleucine 1.55 0.29 0.63 0.09 0.63 0.09 0.68 0.17
Xenobiotics 2-pyrrolidinone HMDB02039 Chemical 1.10 0.50 1.46 0.68 1.46 0.68 1.45 1.17
dihydrokaempferol Food component/Plant 1.00 0.00 1.00 0.00 1.00 0.00 1.00 0.00
ergothioneine HMDB03045 Food component/Plant 1.30 0.23 0.89 0.25 0.89 0.25 0.91 0.30
erythritol HMDB02994 Sugar, sugar substitute, starch 0.95 0.23 1.13 0.19 1.13 0.19 1.06 0.21
glycerol 2-phosphate HMDB02520 Chemical 1.12 0.35 0.90 0.24 0.90 0.24 0.87 0.32
hippurate HMDB00714 Benzoate metabolism 0.74 0.44 0.90 0.32 0.90 0.32 1.08 0.69
ketamine Drug 1.05 1.14 0.72 0.69 0.72 0.69 0.80 0.92
pentobarbital Drug 0.71 0.61 1.02 0.62 1.02 0.62 1.33 0.92