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. Author manuscript; available in PMC: 2015 Sep 7.
Published in final edited form as: J Biomol Screen. 2014 Mar 7;19(7):1060–1069. doi: 10.1177/1087057114526433

Figure 4. Dose response curves of significant hits.

Figure 4

The 9 hit compounds from the primary screen were tested with the TR-FRET assay using a 4-fold dose response series from 1.2nM to 20µM (4 replicates each). Controls are shown as red open circles. Four of the 9 compounds showed a potency for inhibition of MBD2-MBD binding to DNA within the dose range tested. IC50 values for each compound are listed below the title for each dose response.