Table III.
Risk of psoriasis and PsA according to regular use duration of acetaminophen, NSAIDs, and aspirin in the Nurses’ Health Study II (1991–2005)
| 0 | 1–6 y | 7–10 y | ≥11 y | |
|---|---|---|---|---|
| Acetaminophen | ||||
| Psoriasis | ||||
| No. of cases/person-years | 303/688 413 | 154/268 733 | 49/80 609 | 33/32 300 |
| Age-adjusted HR (95% CI) | 1.00 | 1.26 (1.03, 1.53) | 1.26 (0.92, 1.71) | 1.54 (1.06, 2.23) |
| Multivariate HR (95% CI)a | 1.00 | 1.16 (0.96, 1.42) | 1.12 (0.82, 1.53) | 1.33 (0.91, 1.94) |
| Multivariate HR (95% CI)b | 1.00 | 1.14 (0.94, 1.39) | 1.09 (0.80, 1.50) | 1.29 (0.89, 1.89) |
| PsA | ||||
| No. of cases/person-years | 57/688 413 | 48/268 733 | 15/80 609 | 19/32 300 |
| Age-adjusted HR (95% CI) | 1.00 | 2.16 (1.47, 3.19) | 2.23 (1.23, 4.04) | 5.22 (2.96, 9.21) |
| Multivariate HR (95% CI)a | 1.00 | 1.83 (1.24, 2.70) | 1.75 (0.97, 3.18) | 3.79 (2.13, 3.18) |
| Multivariate HR (95% CI)b | 1.00 | 1.77 (1.19, 2.62) | 1.66 (0.91, 3.02) | 3.60 (2.02, 6.41) |
| NSAIDs | ||||
| Psoriasis | ||||
| No. of cases/person-years | 245/582 384 | 168/315 423 | 73/121 158 | 51/47 416 |
| Age-adjusted HR (95% CI) | 1.00 | 1.24 (1.01, 1.52) | 1.27 (0.96, 1.68) | 1.62 (1.16, 2.25) |
| Multivariate HR (95% CI)a | 1.00 | 1.11 (0.91, 1.37) | 1.07 (0.80, 1.42) | 1.30 (0.93, 1.82) |
| Multivariate HR (95% CI)b | 1.00 | 1.09 (0.88, 1.34) | 1.04 (0.78, 1.38) | 1.26 (0.90, 1.76) |
| PsA | ||||
| No. of cases/person-years | 45/582 384 | 46/315 423 | 29/121 158 | 18/47 416 |
| Age-adjusted HR (95% CI) | 1.00 | 2.04 (1.33, 3.14) | 3.26 (1.92, 5.54) | 3.61 (1.93, 6.76) |
| Multivariate HR (95% CI)a | 1.00 | 1.63 (1.06, 2.51) | 2.30 (1.35, 3.91) | 2.32 (1.23, 4.36) |
| Multivariate HR (95% CI)b | 1.00 | 1.51 (0.98, 2.33) | 2.09 (1.22, 3.58) | 2.10 (1.11, 3.96) |
| Aspirin | ||||
| Psoriasis | ||||
| No. of cases/person-years | 385/825 789 | 114/191 386 | 25/43 366 | 18/16 365 |
| Age-adjusted HR (95% CI) | 1.00 | 1.14 (0.92, 1.41) | 0.99 (0.66, 1.50) | 1.38 (0.84, 2.24) |
| Multivariate HR (95% CI)a | 1.00 | 1.01 (0.81, 1.26) | 0.85 (0.56, 1.29) | 1.17 (0.72, 1.92) |
| Multivariate HR (95% CI)b | 1.00 | 0.99 (0.79, 1.23) | 0.83 (0.55, 1.26) | 1.14 (0.70, 1.86) |
| PsA | ||||
| No. of cases/person-years | 96/825 789 | 32/191 386 | 9/43 366 | 4/16 365 |
| Age-adjusted HR (95% CI) | 1.00 | 1.18 (0.78, 1.78) | 1.29 (0.64, 2.61) | 1.04 (0.37, 2.91) |
| Multivariate HR (95% CI)a | 1.00 | 0.94 (0.62, 1.43) | 0.97 (0.47, 1.96) | 0.78 (0.28, 2.19) |
| Multivariate HR (95% CI)b | 1.00 | 0.88 (0.58, 1.33) | 0.90 (0.44, 1.84) | 0.72 (0.26, 2.02) |
a
Multivariate HRs were adjusted for the covariates listed in Table 2 footnote a.
b
HRs were further adjusted for the other drugs (depending on the model) listed in the table.