Table IV.
Risk of psoriasis and PsA according to weekly dosage of acetaminophen, NSAIDs, and aspirin in the Nurses’ Health Study II (1999–2005)
| 0 | 1–5 tablets/week | ≥ 6 tablets/week | |
|---|---|---|---|
| Acetaminophen | |||
| Psoriasis | |||
| No. of cases/person-years | 149/262 051 | 65/75 291 | 35/29 465 |
| Age-adjusted HR (95% CI) | 1.00 | 1.44 (1.08, 1.93) | 1.98 (1.37, 2.86) |
| Multivariate HR (95% CI)a | 1.00 | 1.34 (1.00, 1.80) | 1.59 (1.10, 2.32) |
| Multivariate HR (95% CI)b | 1.00 | 1.37 (1.01, 1.84) | 1.62 (1.11, 2.37) |
| PsA | |||
| No. of cases/person-years | 29/262 051 | 21/75 291 | 16/29 465 |
| Age-adjusted HR (95% CI) | 1.00 | 2.44 (1.39, 4.28) | 4.48 (2.43, 8.26) |
| Multivariate HR (95% CI)a | 1.00 | 2.14 (1.22, 3.76) | 3.04 (1.63, 5.67) |
| Multivariate HR (95% CI)b | 1.00 | 2.12 (1.20, 3.77) | 3.05 (1.63, 5.70) |
| NSAIDs | |||
| Psoriasis | |||
| No. of cases/person-years | 114/183 634 | 75/103 485 | 51/71 547 |
| Age-adjusted HR (95% CI) | 1.00 | 1.13 (0.84, 1.51) | 1.13 (0.81, 1.58) |
| Multivariate HR (95% CI)a | 1.00 | 1.06 (0.79, 1.42) | 0.94 (0.67, 1.31) |
| Multivariate HR (95% CI)b | 1.00 | 1.00 (0.74, 1.35) | 0.91 (0.65, 1.28) |
| PsA | |||
| No. of cases/person-years | 22/183 634 | 13/103 485 | 23/71 547 |
| Age-adjusted HR (95% CI) | 1.00 | 1.03 (0.52, 2.04) | 2.56 (1.43, 4.60) |
| Multivariate HR (95% CI)a | 1.00 | 0.92 (0.46, 1.84) | 1.83 (1.01, 3.32) |
| Multivariate HR (95% CI)b | 1.00 | 0.79 (0.39, 1.59) | 1.66 (0.91, 3.02) |
| Aspirin | |||
| Psoriasis | |||
| No. of cases/person-years | 197/315 268 | 19/16 829 | 15/11 203 |
| Age-adjusted HR (95% CI) | 1.00 | 1.39 (0.85, 2.25) | 1.56 (0.91, 2.68) |
| Multivariate HR (95% CI)a | 1.00 | 1.27 (0.78, 2.06) | 1.23 (0.71, 2.12) |
| Multivariate HR (95% CI)b | 1.00 | 1.20 (0.74, 1.96) | 1.20 (0.69, 2.07) |
| PsA | |||
| No. of cases/person-years | 50/315 268 | 6/16 829 | 4/11 203 |
| Age-adjusted HR (95% CI) | 1.00 | 1.68 (0.70, 4.04) | 1.52 (0.53, 4.34) |
| Multivariate HR (95% CI)a | 1.00 | 1.43 (0.59, 3.44) | 1.02 (0.35, 2.93) |
| Multivariate HR (95% CI)b | 1.00 | 1.23 (0.51, 2.98) | 0.95 (0.33, 2.74) |
a
Multivariate HRs were adjusted for the covariates listed in Table 2 footnote a.
b
HRs were further adjusted for the other drugs (depending on the model) listed in the table.