Table 3.
Association of IL1B genotype patterns with moderate to severe chronic periodontitis in the discovery study
| IL1B genotype patterna | Frequency in case | Frequency in control | OR (95% CI)b | p valueb |
|---|---|---|---|---|
| 3 | 0.42 | 0.28 | 1.87 (1.42–2.46) | < 0.0001 |
| 15 | 0.55 | 0.43 | 1.55 (1.20–2.00) | 0.0009 |
| 20 | 0.53 | 0.43 | 1.54 (1.19–1.99) | 0.001 |
| 22 | 0.53 | 0.42 | 1.48 (1.14–1.92) | 0.004 |
| 29 | 0.57 | 0.44 | 1.66 (1.29–2.15) | < 0.0001 |
a
Patterns indicate pairs of IL1B promoter haplotypes comprised of IL1B rs16944; rs1143623; and rs4848306. In some cases, IL1B rs1143633 further defines whether the IL1B promoter haplotype pair is included in the pattern. Further details of definitions of patterns appear in Table 2.
b
Adjusted for smoking and diabetes.