Table 3.
Age- and multivariate-adjusted RRs for the association of adiposity measurements with risk of psoriatic arthritis among participants with confirmed psoriasis
| Cases | Person- years | Age-adjusted RR (95% CI) | Multivariate- adjusted RR * (95% CI) | |
|---|---|---|---|---|
| Updated BMI (kg/m2) | 146 | 6,838 | ||
| <25.0 | 40 | 3,245 | 1.00 | 1.00 |
| 25.0–29.9 | 35 | 1,533 | 1.80 (1.12–2.88) | 1.81 (1.12–2.93) |
| 30.0–34.9 | 28 | 1,051 | 1.98 (1.19–3.28) | 1.90 (1.13–3.18) |
| ≥35.0 | 43 | 1,009 | 2.97 (1.88–4.69) | 2.98 (1.86–4.78) |
| P for trend | <0.0001 | <0.0001 | ||
| BMI at age 18 (kg/m2) | 145 | 6,791 | ||
| <21.0 | 67 | 3,265 | 1.23 (0.77–1.96) | 1.28 (0.79–2.06) |
| 21.0–22.9 | 26 | 1,668 | 1.00 | 1.00 |
| 23.0–24.9 | 24 | 858 | 1.74 (0.98–3.09) | 1.73 (0.96–3.13) |
| 25.0–29.9 | 17 | 610 | 1.69 (0.89–3.20) | 1.69 (0.88–3.26) |
| ≥30.0 | 11 | 390 | 1.61 (0.76–3.42) | 1.53 (0.71–3.29) |
| P for trend | 0.10 | 0.20 | ||
| Weight change from age 18 (lb) | 145 | 6,791 | ||
| Loss or increase of < 20.0 | 32 | 2,669 | 1.00 | 1.00 |
| Increase of 20.0–49.9 | 45 | 2,285 | 1.36 (0.84–2.18) | 1.34 (0.82–2.17) |
| Increase of 50.0–99.9 | 50 | 1,513 | 2.31 (1.46–3.68) | 2.42 (1.49–3.91) |
| Increase of ≥100.0 | 18 | 324 | 3.28 (1.76–6.11) | 3.84 (1.93–7.63) |
| P for trend | <0.0001 | <0.0001 | ||
| Waist circumference (inch) | 72 | 3,272 | ||
| Tertile 1, <28.0 | 7 | 746 | 1.00 | 1.00 |
| Tertile 2, 28.0–31.9 | 17 | 1,045 | 1.67 (0.63–4.38) | 1.46 (0.54–3.99) |
| Tertile 3, ≥32.0 | 48 | 1,481 | 3.23 (1.36–7.69) | 3.02 (1.21–7.56) |
| P for trend | 0.002 | 0.004 | ||
| Hip circumference (inch) | 70 | 3,245 | ||
| Tertile 1, <38.0 | 13 | 931 | 1.00 | 1.00 |
| Tertile 2, 38.0–40.9 | 13 | 917 | 1.31 (0.56–3.05) | 1.24 (0.51–3.00) |
| Tertile 3, ≥41.0 | 44 | 1,397 | 2.35 (1.15–4.79) | 2.59 (1.18–5.69) |
| P for trend | 0.009 | 0.006 | ||
| Waist-Hip Ratio | 70 | 3,245 | ||
| Tertile 1, <0.744 | 12 | 1,008 | 1.00 | 1.00 |
| Tertile 2, 0.744–0.800 | 20 | 996 | 1.43 (0.67–3.06) | 1.41 (0.63–3.15) |
| Tertile 3, >0.800 | 38 | 1,241 | 2.36 (1.18–4.74) | 2.48 (1.20–5.15) |
| P for trend | 0.009 | 0.008 |
Abbreviations: BMI, body mass index; CI, confidence interval; RR, relative risk.
*
Adjusted for age (continuous variable), smoking (never, past, current with 1–14, 15–24, or ≥25 cigs/day), alcohol drinking (no, <4.9, 5.0–9.9, 10–14.9, 15–29.9 or ≥30.0 g/d), vigorous physical activity (metabolic equivalent hours/wk, in quintile), and height (inches, for the analysis of waist circumference, hip circumference, and waist-hip ratio), and weight at 18 years (for the analysis of weight change from 18 y).