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. 2014 Aug 13;289(40):27410–27417. doi: 10.1074/jbc.M114.591735

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — GX sPLA₂-mediated regulation of GSIS. GX sPLA₂ hydrolysis of cellular membrane phospholipids generates arachidonic acid (AA), which is converted to PGE2 in a COX2-dependent manner. PGE2 released from the cell binds the EP3 receptor on the cell surface, leading to reduced cellular cAMP content and suppressed GSIS. The cellular membrane(s) hydrolyzed by GX sPLA₂ to release AA have not been delineated. GX sPLA₂ may generate AA during (1) or after (2) its secretion from cells, or subsequent to re-uptake (3).